PA4608 - hypothetical protein-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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881102 PA4608

基因描述

Type	Description
Definition	hypothetical protein

研究结论

Date	Results	Publications
2020-08-12 11:19:00	Cyclic-di-GMP (c-di-GMP) is an important second messenger involved in the regulation of biofilm formation. Among 40 c-di-GMP metabolizing genes, 5 have well-conserved phylogenetic distribution and invariable expression profiles, suggesting that there are enzymes required for the basal level of c-di-GMP in P. aeruginosa.	31444209
2017-09-30 11:14:00	Recently, a single-domain PilZ protein, MapZ (PA4608), was identified to inhibit the activity of the methyltransferase CheR1. Here, crystal structures of the C-terminal domain of CheR1 containing S-adenosylhomocysteine and of CheR1 in complex with c-di-GMP-bound MapZ are reported.	28777083
2011-06-04 11:26:00	Determined the solution structure of c-di-GMP bound PA4608. We found that PA4608 undergoes conformational changes to expose the c-di-GMP binding site by ejection of the C-terminal 3(10) helix.	21280119
2010-01-21 00:00:00	The monomeric core of PA4608 has a 6-stranded antiparallel beta barrel flanked by 3 helices. Conserved surface residues of PA4608 homologs show c-di-GMP binding site is at 1 end of the barrel & has residues in the helices & the unstructured N-terminus.	17096419

名称对应

Type	IDs
Gene	UniProtKB-ID: CDGBP_PSEAE UniprotKB: Q9HVI1 UniParc: UPI00000C5D87 EMBL: AE004091 EnsemblGenome: PA4608 KO: pae:PA4608
Nucleutide sequences	EMBL-CDS: AAG07996.1 EnsemblGenome_TRS: AAG07996
Protein sequencees	EnsemblGenome_PRO: AAG07996 RefSeq: NP_253298.1
Others	UniRef100: UniRef100_Q9HVI1 UniRef90: UniRef90_Q9HVI1 UniRef50: UniRef50_Q9HVI1

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mRNA

Protein

UniprotKB

Description

Refseq

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Ensembl: {{protein.nucleotideEnsembl}}

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Ensembl: {{protein.proteinEnsembl}}

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Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

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Pubmed编号	文献信息	发表日期	相关基因
31444209	Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses. Appl Environ Microbiol Qing Wei , Sebastien Leclercq , Pramod Bhasme , Anming Xu , Bin Zhu , Yuhuan Zhang , Miaokun Zhang , Shiwei Wang , Luyan Z Ma	2019-11-01	-
28777083	Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP. Acta Crystallogr D Struct Biol Yingxiao Zhu , Zenglin Yuan , Lichuan Gu	2017-08-01	-
21280119	Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate. Protein Sci Jae-Sun Shin , Kyoung-Seok Ryu , Junsang Ko , Arum Lee , Byong-Seok Choi	2011-02-01	-
18978025	Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Nucleic Acids Res. Geoffrey L Winsor , Thea Van Rossum , Raymond Lo , Bhavjinder Khaira , Matthew D Whiteside , Robert E W Hancock , Fiona S L Brinkman	2009-01-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
17096419	NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Proteins Theresa A Ramelot , Adelinda Yee , John R Cort , Anthony Semesi , Cheryl H Arrowsmith , Michael A Kennedy	2007-02-01	PA4608
17015649	Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. J. Bacteriol. Ryan T Cirz , Bryan M O'Neill , Jennifer A Hammond , Steven R Head , Floyd E Romesberg	2006-10-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
16030221	Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. J. Bacteriol. Kelli L Palmer , Lauren M Mashburn , Pradeep K Singh , Marvin Whiteley	2005-08-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
15995206	A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J. Bacteriol. Prabhakar Salunkhe , Catherine H M Smart , J Alun W Morgan , Stavroula Panagea , Martin J Walshaw , C Anthony Hart , Robert Geffers , Burkhard TÃ¼mmler , Craig Winstanley	2005-07-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
15908409	Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Infect. Immun. M J Filiatrault , V E Wagner , D Bushnell , C G Haidaris , B H Iglewski , L Passador	2005-06-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341
15716452	Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J. Bacteriol. Thomas Bovbjerg Rasmussen , Thomas Bjarnsholt , Mette Elena Skindersoe , Morten Hentzer , Peter Kristoffersen , Manuela KÃ¶te , John Nielsen , Leo Eberl , Michael Givskov	2005-03-01	PA2755a, PA4636a, PA0032a, PA0041a, PA0103a, PA0306a, PA0367a, PA0451a, PA0701a, PA0736a, PA0788a, PA0951a, PA1019a, PA1052a, PA1112a, PA1112b, PA1424a, PA1428a, PA1483a, PA1578a, PA1643a, PA1797a, PA1833a, PA1837a, PA1866a, PA2118a, PA2142a, PA2173a, PA2312a, PA2559a, PA2746a, PA2747a, PA2750a, PA2754a, PA2763a, PA2772a, PA3089a, PA3303a, PA3403a, PA3440a, PA3574a, PA3733a, PA3865a, PA3886a, PA3963a, PA3969a, PA4027a, PA4108a, PA4145a, PA4313a, PA4360a, PA4635a, PA4690a, PA5183a, PA5252a, PA5440a, PA0457.1, pyoS5, PA1021, PA0123, PA0891, PA1020, PA0440, PA0007, lptA, PA0116, PA0119, PA1159, PA0439, codB, PA0878, PA2296, PA0512, PA0118, codA, PA1734, PA0848, PA1168, cmpX, PA0436, PA0699, PA0305, PA0753, PA0049, PA1870, PA0628, PA1831, PA0624, PA0708, PA0435, PA0434, flgB, arsC, PA5108, PA5109, PA0978, PA0919, PA5340, PA5341

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