[No authors listed]
OBJECTIVE:The objective of the study was to study the genetic risk factors of spontaneous preterm birth (PTB) in African Americans. STUDY DESIGN:Case-control analyses were performed using maternal and fetal deoxyribonucleic acid from 279 African American birth events (82 PTB and 197 term) and 1432 single-nucleotide polymorphisms from 130 candidate genes. Single-locus association and haplotype analyses were performed. RESULTS:The most significant associations were in the maternal interleukin (IL)-15 (rs10833, allele P = 2.91 x 10(-4), genotype P = 2.00 x 10(-3)) gene and the fetal IL-2 receptor B (IL-2RB) (rs84460, allele P = 1.37 x 10(-4), genotype P = 6.29 x 10(-4)) gene. The best models for these markers were additive (rs10833, odds ratio [OR], 0.30; 95% confidence interval [CI], 0.14-0.62; P = 1.0 x 10(-3); rs84460, OR, 2.32; 95% CI, 1.47-3.67; P < 1.0 x 10(-3)). The largest number of significant associations was found in genes related to infection and inflammation. There were overall a larger number of significant associations in infants than in mothers. CONCLUSION:These results support a strong role for genes involved in infection and inflammation in the pathogenesis of PTB, particularly IL-12 and IL-12RB, and indicate that in African Americans there may be complementarity of maternal and fetal genetic risks for PTB.
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NAT2, PGRMC2, PGRMC1, ADH1B, ADH1C, COL1A1, COL3A1, COL5A1, COL5A2, CRH, CRHBP, CRHR1, CRHR2, CRP, CTLA4, ADRB2, CYP1A1, CYP2D6, CYP19A1, ACE, PTCRA, DHFR, EDN2, EPHX1, EPHX2, F2, F5, F7, CBY1, PTPN22, NR3C1, GSTP1, GSTT2, HSD11B1, HSPA1A, HSPA1B, HSPA1L, HSPA4, HSPA6, IFNG, IGF1, IGFBP3, FAS, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL2, IL2RA, IL2RB, FASLG, IL4, IL4R, IL5, IL6, IL6R, CXCL8, CXCR1, IL10, IL10RA, IL10RB, IL13, IL15, IL18, MBL2, MMP1, MMP2, MMP3, MMP8, MMP9, MTHFD1, MTHFR, NFKB1, NFKBIE, NOS3, PAFAH1B1, PAFAH1B2, SERPINE1, HSPA14, TLR7, TLR8, HSD17B7, PGR, PLA2G4A, PLAT, TLR9, TREM1, POMC, PON1, PON2, UGT1A1, PTGER2, PTGER3, PTGFR, PTGS1, PTGS2, SCNN1A, CCL2, CCL3, CCL8, NOD2, SLC6A4, TCN2, TGFB1, TIMP3, TIMP4, TLR2, TLR3, TNF, TNFRSF1A, TNFRSF1B, TRAF2, TSHR, SCGB1A1, VEGFA, IL1R2, LST1, SERPINH1, CBS, NAT1, CD14, KL, PTGES, SLC23A1
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