| Type | Description |
|---|---|
| Definition | interleukin 10 receptor subunit beta |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:01:00 | Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130. | 32611765 |
| 2019-04-06 11:50:00 | analysis of two novel copy number variations in IL10RB, one with founder effect and one preserving cell surface expression but abolishing signaling | 30365510 |
| 2018-11-03 11:44:00 | IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2. | 30247785 |
| 2018-02-24 11:31:00 | We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations. | 28267044 |
| 2018-01-13 14:09:00 | IL-10 and IL-10R gene polymorphisms may not contribute to the susceptibility to MM but may be associated with the severity and prognosis of MM. In particular, IL-10RB K47E polymorphism may contribute to the poor prognosis of MM patients treated with thalidomide and/or bortezomib. | 27405747 |
| Type | IDs |
|---|---|
| Synonymous | CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2 |
| Gene |
UniProtKB-ID:
I10R2_HUMAN
UniprotKB:
Q08334
UniParc:
UPI0000072ECA
EMBL:
BT009777,
BC001903,
Z17227,
U08988,
AY323826
Ensembl:
ENSG00000243646
KO:
hsa:3588
|
| Nucleutide sequences |
EMBL-CDS:
AAH01903.1,
AAA86872.1,
CAA78933.1,
AAP88779.1,
AAP72016.1
Ensembl_TRS:
ENST00000290200
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000290200
RefSeq:
NP_000619.3
|
| Others |
UniRef100:
UniRef100_Q08334
UniRef90:
UniRef90_Q08334
UniRef50:
UniRef50_Q08334
UniGene:
Hs.654593
CCDS:
CCDS13623.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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