| Type | Description |
|---|---|
| Definition | dihydrofolate reductase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:42:00 | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | 32391884 |
| 2020-05-02 12:24:00 | Casein kinase 2 alpha strongly interacts with and phosphorylates dihydrofolate reductase. | 30961929 |
| 2020-05-02 12:05:00 | Variants in TYMS, SLC19A1 and DHFR genes are potential biomarkers of myelotoxicity and could be used for 6-MP therapy individualization in maintenance phase of childhood ALL treatment, alongside with well-established TPMT variants. | 31786878 |
| 2020-03-14 10:11:00 | These results indicated that hDHFR is not the only target of Pyr. We further found that thymidine phosphorylase (TP), an enzyme that is closely associated with the EMT of cancer cells, is also a target protein of Pyr. The data retrieved from the Cancer Genome Atlas (TCGA) database revealed that TP overexpression is associated with poor prognosis of patients with lung cancer | 30642883 |
| 2020-01-25 12:19:00 | Results showed that the dominant alleles in three genes (DHFR, MTHFR, TYMS) were associated with hematologic toxicity, but none of them was associated with methotrexate level, hepatotoxicity or renal function | 30684021 |
| Type | IDs |
|---|---|
| Synonymous | DHFRP1, DYR |
| Gene |
UniProtKB-ID:
DYR_HUMAN,
B4DM58_HUMAN,
B0YJ76_HUMAN
UniprotKB:
P00374,
B4DM58,
B0YJ76
UniParc:
UPI000020CBBC,
UPI0000161B19,
UPI00017A754B
EMBL:
X00857,
X00855,
X00858,
BC070280,
BC000192,
K01612,
AK293146,
AC010270,
BC003584,
X00859,
EU145592,
AC008434,
K01614,
BC071996,
J00138,
J00140,
AK297302,
K01613,
X00856,
V00507,
EF445014,
AK312642,
J00139
Ensembl:
ENSG00000228716
KO:
hsa:1719
|
| Nucleutide sequences |
EMBL-CDS:
BAG56693.1,
AAH00192.1,
AAH03584.2,
AAA58484.1,
CAA25409.1,
AAA58485.1,
AAH71996.1,
AAH70280.1,
CAA23765.1,
BAG59770.1,
ACA06052.1,
ABX57718.1,
BAG35526.1
Ensembl_TRS:
ENST00000505337,
ENST00000439211,
ENST00000504396,
ENST00000511032
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000396308,
ENSP00000421334,
ENSP00000426474,
ENSP00000422732
RefSeq:
NP_001277283.1,
NP_000782.1,
NP_001277286.1
|
| Others |
UniRef100:
UniRef100_B4DM58,
UniRef100_P00374
UniRef90:
UniRef90_B4DM58,
UniRef90_P00374
UniRef50:
UniRef50_P00374,
UniRef50_B4DM58
UniGene:
Hs.592364,
Hs.648635
CCDS:
CCDS78028.1,
CCDS47240.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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