| Type | Description |
|---|---|
| Definition | thyroid stimulating hormone receptor |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:32:00 | The Human TSHbeta Subunit Proteins and Their Binding Sites on the TSH Receptor Using Molecular Dynamics Simulation. | 32738139 |
| 2020-06-13 12:28:00 | Findings showed that PTC patients carrying the TSHR rs2288496 TC and CC variants were associated with higher TSH level and lower T4 and Anti-TG levels and were prone to developing LNM. | 31658048 |
| 2020-04-04 11:48:00 | Activating TSHR mutations are a rare cause of nonautoimmune adult hyperthyroidism. This study does not support the routine genetic testing in adult patients with hyperthyroidism showing diffuse uptake on scintigraphy but negative TRAb and lacking extrathyroidal manifestations of Graves' disease. | 30372544 |
| 2020-03-28 10:32:00 | The Pathogenic TSH beta-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR. | 31703413 |
| 2020-02-29 11:30:00 | Aberrant TSH receptor signaling modulates tumor angiogenesis by stimulating VEGF-A and CXCL8 secretion from poorly differentiated thyroid cancer cells and enhances tumor growth; thus, TSH suppression is beneficial for treating poorly differentiated thyroid cancer . | 30314969 |
| Type | IDs |
|---|---|
| Synonymous | CHNG1, LGR3, hTSHR-I |
| Gene |
UniProtKB-ID:
TSHR_HUMAN,
A0A0A0MTJ0_HUMAN
UniprotKB:
P16473,
A0A0A0MTJ0
UniParc:
UPI00018830B9,
UPI000013E4A2,
UPI000006E162,
UPI000018684A
EMBL:
BC120973,
S49816,
AL136040,
AC007262,
M31774,
BC024205,
AC010582,
AC010072,
M32215,
BC127628,
BC009237,
M73747,
BC063613,
S45272,
BC108653,
BC141970,
AY429111
Ensembl:
ENSG00000165409
KO:
hsa:7253
|
| Nucleutide sequences |
EMBL-CDS:
AAH09237.1,
AAH63613.1,
AAF09032.1,
AAD31568.1,
AAR07906.1,
AAB23390.2,
AAI08654.1,
AAI20974.1,
AAB24246.1,
AAI41971.1,
AAI27629.1,
AAH24205.1,
AAA61236.1,
AAF26775.1,
AAA70232.1,
AAA36783.1
Ensembl_TRS:
ENST00000554435,
ENST00000342443,
ENST00000298171,
ENST00000541158
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000450549,
ENSP00000340113,
ENSP00000441235,
ENSP00000298171
RefSeq:
XP_006720308.1,
XP_011535421.1,
NP_001136098.1,
NP_000360.2,
XP_005268096.1,
NP_001018046.1,
XP_005268094.1
|
| Others |
UniRef100:
UniRef100_A0A0A0MTJ0,
UniRef100_P16473
UniRef90:
UniRef90_P16473
UniRef50:
UniRef50_P16473
UniGene:
Hs.160411
CCDS:
CCDS9872.1,
CCDS55935.1,
CCDS32131.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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