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6337 SCNN1A

6337

SCNN1A

sodium channel epithelial 1 alpha subunit

protein-coding

Homo sapiens

基因描述

Type Description
Definition sodium channel epithelial 1 alpha subunit

研究结论

Date Results Publications
2021-02-06 13:49:00 miR95 promotes osteosarcoma growth by targeting SCNN1A. 32323794
2020-11-21 13:18:00 MLL2 regulates glucocorticoid receptor-mediated transcription of ENACalpha in human retinal pigment epithelial cells. 32139118
2020-10-03 12:56:00 Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption. 31936044
2020-05-09 10:17:00 Epithelial Na(+) channel's (ENaC) able to mediate shear force responsiveness relies on the "force-from-filament" principle involving extracellular tethers and the extracellular matrix. Two glycosylated asparagines, respectively their N-glycans localized in the palm and knuckle domains of alphaENaC, were identified as potential tethers. Endothelial-specific overexpression of alphaENaC in mice induced hypertension. 31871197
2020-04-11 12:34:00 SCNN1A silence remarkably blocked SK-OV-3 cell growth ability, migration, and invasion potential. Western blotting results showed that SCNN1A silence led to an increase in E-cadherin, whereas a decrease in N-cadherin, Vimentin, and Snail in SK-OV-3 cells. 31549859

名称对应

Type IDs
Synonymous BESC2, ENaCa, ENaCalpha, LIDLS3, SCNEA, SCNN1
Gene
UniProtKB-ID: SCNNA_HUMAN
UniprotKB: P37088
UniParc: UPI00001B07D8, UPI00017A8672, UPI00001B07D7, UPI00001B07DA, UPI00001B07D9, UPI0000000DC4
EMBL: U81961, AC006057, BC062613, Z92980, AF060912, AF060910, AC005840, FJ515830, AK304379, AF060913, L29007, BC006526, AF060911, Z92981, CH471116, Z92978, X76180, DQ402522, Z92979
Ensembl: ENSG00000111319
KO: hsa:6337
Nucleutide sequences
EMBL-CDS: EAW88804.1, CAA53773.1, CAB07505.1, ACS13721.1, AAC31774.1, BAG65217.1, AAA21813.1, AAD28355.1, AAC31773.1, AAH62613.1, AAH06526.2, ABD72218.1
Ensembl_TRS: ENST00000543768, ENST00000228916, ENST00000360168
Protein sequencees
Ensembl_PRO: ENSP00000228916, ENSP00000438739, ENSP00000353292
RefSeq: NP_001153047.1, NP_001153048.1, NP_001029.1
Others
UniRef100: UniRef100_P37088
UniRef90: UniRef90_P37088
UniRef50: UniRef50_P37088
UniGene: Hs.591047
CCDS: CCDS53738.1, CCDS8543.1, CCDS53739.1

全选

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