Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits.
[No authors listed]
摘要
Most organisms exhibit senescence; a decline in physiological function with age. In nature, rates of senescence vary extensively among individuals and this variation has a significant genetic component; however, we know little about the genes underlying senescence. Here we show the first evidence that individual alleles influence fecundity in an age-specific manner and so the genetic basis of natural variation in fecundity changes dramatically with age. We complete a genome-wide association to identify single-nucleotide polymorphisms (SNPs) affecting lifespan and age-specific fecundity using the Drosophila melanogaster Genetic Reference Panel. We identify 1,031 SNPs affecting fecundity and 52 influencing lifespan. Only one SNP is associated with both early- and late-age fecundity. The age-specific effect of candidate genes on fecundity is validated using RNA interference. In addition, there is a dramatic increase in the number of SNPs influencing fecundity with age. This result provides support for the mutation accumulation theory of aging.
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基因功能
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基因
CR42756, clt, CG43449, CR17025, CG43156, CG43054, CR40282, CR43281, HP1Lcsd, CG43245, CG43120, CG43400, CG43350, CR43621, CG43202, CG43439, CR43453, CR43465, CG43732, CR43811, CR43830, CR43825, CG32032, CG32388, CR32773, CR42736, CR43681, CG30274, CG30291, Proc, Fatp, dpr9, CG33483, Ir41a, CG34330, CG33489, zormin, CG14050, CG2652, kirre, bi, CG15765, CG6067, Ca-alpha1T, CG34417, CG14440, CG3168, RpL17, CG12541, CG1677, nAChRalpha3, Nrg, CG33791, jv, TwdlZ, CG12075, CG32834, rdgA, CG15365, CG31267, CG31268, CG31609, CG33181, NimA, CG31810, RhoU, CG43902, CG32687, spri, CG32676, pot, cac, Ten-a, CG42258, Pde9, CG43313, mew, Neto, Tango13, CG9413, NetA, Cngl, kat80, CG4928, CG5004, OdsH, Sh, CG6123, CG43759, CG14190, CG14191, CG7423, pico, shakB, CG11227, ush, CG4341, IA-2, robo3, CG5440, NLaz, chinmo, CG7289, CG31690, CG14300, Ddr, form3, IntS3, Gprk1, RpL5, CG14464, conu, CG17528, Nipped-B, CG12547, CG40486, bark, ed, H15, DIP-theta, CG9171, rau, dsf, Ucp4B, chic, CG31635, cup, sens-2, Rca1, l(2)k09022, Wnt6, CG5958, CG5973, Rbsn-5, CG8086, d, CG13088, Dh31, Sema-1a, CG9483, rost, DIP-zeta, CG12439, tai, CG13110, gcm, nAChRalpha6, CG44153, Sur, CG5367, RluA-1, Trim9, CG7329, CG17097, CG17098, Samuel, Ca-beta, kek2, bun, CG15483, Ance-3, CG33090, Rab14, osp, beat-Ib, beat-Ic, CG5888, Tpr2, ChLD3, ppk17, Mhc, CG13284, tweek, CG15147, CG5758, Socs36E, CG7200, CG42750, Fas3, tup, Lim3, CG10337, Tep4, CG13077, spi, Lar, sick, CG43861, CG9265, tadr, Atf6, laccase2, CG30440, Cyp6w1, CG8343, Ptr, Trap1, Fmo-2, geminin, sced, CG15236, LRR, CG12825, CG12824, Dgk, CG12769, Lpin, pdm3, CG12780, hig, Drep2, oys, psq, CG13229, shn, sha, otk, CG8888, vis, achi, Su(z)2, CG17048, CG6145, CG12464, Cpr50Ca, Cpr50Cb, shot, AGO1, Cp1, CG10202, Pcf11, CG10265, chn, CG8405, CG8441, clu, CG15711, CG17290, CG17287, mbl, CG14502, IM23, IM1, CG15067, Mctp, tn, CG15118, CG10737, cora, Tab2, Rep, Obp56h, Toll-7, CG12484, rig, CG17999, CG9993, CG15227, CG15649, CG9346, ASPP, Sdc, MESK2, PTP-ER, CG10321, pirk, CG13492, CG4377, CG4372, CG9294, comr, Snp, Synj, CG11073, CG34205, CG11170, CG11275, Liprin-gamma, CG10344, ppk12, CG10384, px, CG4269, CG4294, CG4250, CG42260, CG42284, CG12782, CG30412, CG3502, CG33922, Msp300, tRNA:CR30406, Meltrin, snoRNA:Psi28S-3436b, CG18170, tRNA:K2:56EF, tRNA:R2:42Aa, St3, Pal2, Sesn, CG30419, CG3640, CG4781, Hipk, bab1, CG9134, CG32333, CG7991, mv, MsR1, CG13801, CG1317, CG45186, CG16758, Fife, Mrtf, CG12093, Eip63E, CG11594, Cpr64Ab, CG14997, dyl, CG42540, RhoGEF64C, Con, shep, blanks, lin-28, vn, CG5568, CG18586, CG6462, Jon65Aiv, Ets65A, sfl, GluRIA, bin, Mp, unc-13-4A, eco, CG32365, CG13676, Cpr66D, CG13308, CG13309, dally, Tsp66E, Argk, fry, CG42268, CG8177, dpr10, Or67c, A2bp1, tna, Cpr67Fb, Aps, NaPi-III, chrb, Mob2, CG5906, CCDC151, CG5897, Ncc69, sowah, Atg1, CG10960, caps, Tgi, DCTN1-p150, CG32137, upSET, Ptip, CG32138, Sox21a, Sox21b, bbg, dlp, Tom, Brd, CG16959, Msh6, CrebA, pHCl, CG13024, Nc73EF, CG3764, Rbp6, CG6479, CG13731, blot, Eip74EF, Prestin, skl, AstC-R2, ftz-f1, Shal, Oat, tey, CG8004, RhoGDI, Ac76E, fln, CG11404, Trxr-2, pum, CG8147, RhoL, Glut4EF, CG6465, CG14688, CG31388, pros, dpr5, CG6834, Fer3, CG14717, CG14718, I-t, CG14720, svp, CG6753, Dtg, CG6225, Past1, Ace, CG8630, Osi22, wntD, poly, CG9813, CG9925, CG14356, cv-c, jvl, CG6236, ea, CG45105, Zip89B, CG16941, Irc, CG31266, beat-IIa, CREG, Sur-8, CG14329, Pxt, CG14317, sr, CG7694, CG34282, CG42613, CG14282, CG5555, vib, unc79, Dys, Ire1, Arc42, Ask1, Nlg4, MtnC, slmb, CG5810, C15, CG31176, CG17843, CG7031, CG13840, klg, Irk1, CG10184, CG5991, Orct, nAChRalpha1, REPTOR, Saf-B, msi, TwdlM, beat-VII, amon, CG6051, grass, CG5909, CG42534, CG13972, CG12885, Mst98Cb, DIP-gamma, Ptp99A, sima, CG18404, Cyp4c3, Ptx1, CG11340, CG34115, CG34109, sif, axo, Men-b, wb, sns, eIF5B, arr, ome, Vha16-1, scrib, GluRIB, rg, SmD1, raw, ogre, milt, cpo, grau, fs(1)M3, Gug, Spn, Mst98Ca, Eip63F-1, Pgant35A, Atpalpha, IM2, Spn28F, IM4, IM3, COX7C, dpr6, CG13315, Grip, CG6115, Ugt36Bb, larp, Debcl, CG34236, Snoo, CG34245, CG34356, Rgk3, Fili, CG44837, CG34354, CG34310, CG34370, CG34353, CG34309, CG34347, CG34382, CG34251, CG18765, CG18769, CG42356, CG43127, CG42521, mgl, Sfp26Ac, CG42566
原始数据
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文献解读
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