| Type | Description |
|---|---|
| Definition | supernumerary limbs |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:52:00 | Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. | 32129710 |
| 2020-12-12 13:28:00 | The E3 ubiquitin ligase Slimb/beta-TrCP is required for normal copper homeostasis in Drosophila. | 32502619 |
| 2020-02-15 11:08:00 | Here, the authors show that the Casein Kinase 1 (CKI) family is required for Expanded phosphorylation. CKI expression promotes Expanded phosphorylation and interaction with Slimb/beta-TrCP. | 31567070 |
| 2017-12-30 12:01:00 | Our data revealed a new link to understand the underlying mechanism for Nerfin-1 turnover in post-translational level, and provided useful insights in animal development and disease treatment by manipulating the activity of Slimb and Nerfin-1. | 29154825 |
| 2017-05-27 11:04:00 | Interaction with Slimb leads to the ubiquitination and degradation of dSmurf, resulting in negative regulation of dSmurf-mediated Yki phosphorylation and activity in the Hippo pathway. Thus our study revealed a new regulatory mechanism of the Hippo pathway which may provide implications for developing tumor treatment. | 27856247 |
| Type | IDs |
|---|---|
| Synonymous | BcDNA:GM02031, CG3412, Dmel\CG3412, FBXW1, MENE (3R)-B, MENE(3R)-B, SLIMB, SLMB, Slimb, Slimb/Beta-TRCP1, Slimb/beta-TRCP, Slimb/beta-TrCP, Slimb/betaTrCP, Slmb, betaTrCP, crd, ica, l(3)00295, shv, slimb, wel |
| Gene |
UniProtKB-ID:
Q9VDE3_DROME,
A0A0B4KHK1_DROME
UniprotKB:
Q9VDE3,
A0A0B4KHK1
UniParc:
UPI0000083ECA,
UPI000293E9EF
EMBL:
AE014297,
AF222923,
AF222924,
AY118898
EnsemblGenome:
FBgn0283468
KO:
dme:Dmel_CG3412
|
| Nucleutide sequences |
EMBL-CDS:
AAF63214.1,
AAF63213.1,
AGB96181.1,
AAM50758.1,
AAF55853.1,
AGB96182.1
Gene_ORFName:
Dmel_CG3412,
CG3412,
Dmel_CG3412,
CG3412
EnsemblGenome_TRS:
FBtr0333931,
FBtr0084032,
FBtr0330049
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0083434,
FBpp0306059,
FBpp0303082
RefSeq:
NP_001262802.1,
NP_001262801.1,
NP_524430.1
|
| Others |
UniRef100:
UniRef100_A0A0B4KHK1
UniRef90:
UniRef90_A0A0B4KHK1
UniRef50:
UniRef50_Q9UKB1-2
UniGene:
Dm.2387
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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