Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
[No authors listed]
摘要
The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.
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基因功能
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基因
Nidd4n, Bwq3, Bwq4, Nidd3n, Nidd2n, Nidd1n, Ampd2, Srsf1, Obq4, Obq5, Insq3, Insq2, Insq4, Insq5, Dob2, Bw8, Bw5, Bw7, Dob7, Bw4, Dob9, Bw11, Bw13, Bw18, Bw15, Mobq2, Mobq4, Mobq3, Bglq3, Wt6q1, Wt6q3, Wt10q2, Wt10q1, Wt10q3, C10bw6, Wg3, Wg4, Nidd5, Nidd2, Nidd4, Igfbp3q1, Igfbp3q2, Fglu, Dbsty1, Dbsty2, Dbsty3, Dbsty4, Bwob, Bwtq3, Bwtq4, Bwtq2, Bwtq5, Bwtq6, Bw19, Obq7, Obq13, Obq14, Derl2, Trbv4c1, Cd14, Cdh3, Hps3, Cyp4a10, Dvl2, Ces1e, Fabp2, Fasn, Fgf1, Gdi1, Grb2, Aes, Gsc, H1f0, Idh1, Mdm2, Mdh2, Nid1, Npr3, Pdgfra, Ppm1b, Flna, Rara, Sept8, Kdm5c, Tal1, Tbp, Skp1a, Tef, Spag7, Hsp90b1, Vegfa, Ets1, Mpdu1, Smok1, Shroom3, Fam3c, Desi1, Smo, Rab11fip5, Nhp2, Atp6ap1, Mad2l1, Dbn1, Dusp14, Cacna2d2, Nek6, Flnc, Gpt
原始数据
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文献解读
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