| Type | Description |
|---|---|
| Definition | smoothened, frizzled class receptor |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:27:00 | Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. | 32435793 |
| 2020-11-21 13:23:00 | SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors. | 31873117 |
| 2020-07-04 11:14:00 | Smo deletion mediates articular cartilage degeneration by ADAMTS-5 and Runx2 suppression | 31608494 |
| 2020-01-11 12:14:00 | the relieving effect of Smo knockout mice was attenuated when Pth1r knockout was also applied. Our data suggest a chondrocyte protective effect of suppressing Ihh signaling in temporomandibular joint osteoarthritis (OA) cartilage which is dependent on PTH1R signaling | 31382618 |
| 2019-10-05 11:52:00 | results--combined with signalling studies and molecular dynamics simulations--delineate the structural basis for PTCH1-SMO regulation, and suggest a strategy for overcoming clinical resistance to SMO inhibitors | 31263273 |
| Type | IDs |
|---|---|
| Synonymous | E130215L21Rik, Smoh, bnb, smoothened |
| Gene |
UniProtKB-ID:
SMO_MOUSE,
Q8BJN8_MOUSE,
Q4VBD5_MOUSE
UniprotKB:
P56726,
Q8BJN8,
Q4VBD5
UniParc:
UPI00000EB698,
UPI0000020BB8
EMBL:
FJ883552,
AK081050,
BC096028,
AC069469
Ensembl:
ENSMUSG00000001761
KO:
mmu:319757
|
| Nucleutide sequences |
EMBL-CDS:
BAC38122.1,
ACP30472.1,
AAH96028.1
Ensembl_TRS:
ENSMUST00000001812
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000001812
RefSeq:
NP_795970.3,
XP_006505169.1
|
| Others |
UniRef100:
UniRef100_P56726
UniRef90:
UniRef90_P56726
UniRef50:
UniRef50_P56726
UniGene:
Mm.29279
CCDS:
CCDS19965.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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