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14797 Aes

14797

Aes

amino-terminal enhancer of split

protein-coding

Mus musculus

基因描述

Type Description
Definition amino-terminal enhancer of split

研究结论

Date Results Publications
2019-11-02 10:42:00 The results demonstrate that GRG5 has pleiotropic roles in stem cell biology functioning as a stemness factor and a neural fate specifier. 30214018
2017-02-18 11:16:00 in a transplantation mouse model of liver metastases, expression of Yy2 (and therefore of Aes) is downregulated 27561171
2016-01-16 11:16:00 The finding that Foxh1-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions. 25511461
2011-07-16 11:18:00 Self-renewal induced by AML1/ETO in primary murine progenitors was inhibited when Aes was decreased or absent. 21245488
2011-03-19 10:53:00 The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch signaling by converting active Rbpj transcription complexes into repression complexes on insoluble nuclear matrix. 21251616

名称对应

Type IDs
Synonymous AL024115, Esp1, Grg, Grg-5, Grg5, Tle5
Gene
UniProtKB-ID: TLE5_MOUSE, Q3TYD9_MOUSE, B7ZNK7_MOUSE
UniprotKB: P63002, Q3TYD9, B7ZNK7
UniParc: UPI000002AAC4, UPI0000020C5B, UPI000154B0C3
EMBL: AK131845, L12140, X73359, BC132219, BC132217, AK158714, X73361, BC145299
Ensembl: ENSMUSG00000054452
KO: mmu:14797
Nucleutide sequences
EMBL-CDS: CAA51771.1, AAA03023.1, CAA51769.1, AAI32218.1, BAE20827.1, AAI32220.1, BAE34624.1, AAI45300.1
Ensembl_TRS: ENSMUST00000002518
Protein sequencees
Ensembl_PRO: ENSMUSP00000002518
RefSeq: NP_001263217.1, NP_034477.1
Others
UniRef100: UniRef100_P63002, UniRef100_B7ZNK7
UniRef90: UniRef90_P63002, UniRef90_Q28C95
UniRef50: UniRef50_P63002
UniGene: Mm.180013
CCDS: CCDS24062.1

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