| Type | Description |
|---|---|
| Definition | family with sequence similarity 3, member C |
| Date | Results | Publications |
|---|---|---|
| 2019-02-09 12:05:00 | ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1. | 29871931 |
| 2017-09-30 10:42:00 | Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness. | 28751379 |
| 2017-08-19 11:55:00 | overexpression of Fam3c caused reduction of Runx2 expression at both mRNA and protein levels. Fam3c was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c and TGF-beta1 were found to regulate each other reciprocally | 27914282 |
| 2017-08-19 10:25:00 | In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition. | 28246289 |
| 2017-07-15 10:48:00 | Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. | 27256505 |
| Type | IDs |
|---|---|
| Synonymous | D6Wsu176e, Ilei |
| Gene |
UniProtKB-ID:
FAM3C_MOUSE
UniprotKB:
Q91VU0
UniParc:
UPI0000029252
EMBL:
BC055853,
AK154498,
AK170887,
AK004059,
CH466533,
AY424275,
BC009086
Ensembl:
ENSMUSG00000029672
KO:
mmu:27999
|
| Nucleutide sequences |
EMBL-CDS:
AAR84605.1,
AAH55853.1,
BAB23146.1,
AAH09086.1,
BAE42094.1,
BAE32629.1,
EDL13845.1
Ensembl_TRS:
ENSMUST00000165576
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000127709
RefSeq:
XP_006505165.1,
NP_613053.3,
XP_006505166.1
|
| Others |
UniRef100:
UniRef100_Q91VU0
UniRef90:
UniRef90_Q91VU0
UniRef50:
UniRef50_Q92520
UniGene:
Mm.490307
CCDS:
CCDS39436.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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