| Type | Description |
|---|---|
| Definition | serine/arginine-rich splicing factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 12:49:00 | Loss of SRSF1 limits the expression of the mTOR repressor PTEN, leading to aberrant T cell activation and the expression of systemic autoimmunity. | 31487268 |
| 2018-12-22 12:23:00 | SRSF1 promotes vascular smooth muscle cell (VSMC) proliferation and injury-induced neointima formation. SRSF1 favors the induction of a truncated p53 isoform, Delta133p53, which has an equal proliferative effect and in turn transcriptionally activates Kruppel-like factor 5 (KLF5) via the Delta133p53-EGR1 complex, resulting in an accelerated cell-cycle progression and increased VSMC proliferation. | 28799539 |
| 2018-10-06 10:24:00 | In addition, overexpression of SRSF1 in XRCC4-deficient cells restored the normal level of apoptosis, suggesting that SRSF1 functions downstream of XRCC4 in activating CAD. | 29233683 |
| 2018-07-21 10:53:00 | SRSF1 is a key regulator of DBF4B pre-mRNA splicing dysregulation in colon cancer. SRSF1 is required for cancer cell proliferation. | 29262322 |
| 2018-06-16 11:53:00 | LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin and SRSF1. | 28444861 |
| Type | IDs |
|---|---|
| Synonymous | 1110054N12Rik, 5730507C05Rik, 6330415C05Rik, AI482334, AW491331, Asf, Sf2, Sfrs1 |
| Gene |
UniProtKB-ID:
SRSF1_MOUSE
UniprotKB:
Q6PDM2
UniParc:
UPI00000EB65E,
UPI0000DC1C04,
UPI0000001220
EMBL:
AL593853,
AK018176,
BC058627,
AK078715,
AK150535,
CU406964,
BC046773
Ensembl:
ENSMUSG00000098301,
ENSMUSG00000018379
KO:
mmu:110809
|
| Nucleutide sequences |
EMBL-CDS:
BAC37367.1,
AAH58627.1,
AAH46773.1,
BAC25546.1,
BAE29641.1
Ensembl_TRS:
ENSMUST00000193491,
ENSMUST00000183352,
ENSMUST00000079866,
ENSMUST00000139129
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000120595,
ENSMUSP00000138980,
ENSMUSP00000141939,
ENSMUSP00000133517
RefSeq:
NP_001071635.1,
NP_775550.2
|
| Others |
UniRef100:
UniRef100_Q07955
UniRef90:
UniRef90_Q07955
UniRef50:
UniRef50_Q07955
UniGene:
Mm.391719
CCDS:
CCDS36273.1,
CCDS36274.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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