Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.
Biochem. Biophys. Res. Commun.2007 Nov 30;363(4):926-30. Epub 2007 Sep 25
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摘要
Using RNA interference to suppress gene expression, we attempted to identify tyrosine kinases involved in the extension of neurites from SH-SY5Y cells. A comprehensive analysis of gene "knock-down" profiles with small interfering RNAs (siRNAs) revealed candidate proteins that might control neurite extension. Phenotype-based screening of differentiating SH-SY5Y cells following retinoic acid (RA) stimulation indicated that twinfilin-2 is a protein that is involved in neurite outgrowth, as confirmed by morphological analysis of twinfilin-2-overexpressing cells.
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基因功能
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原始数据
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文献解读
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