| Type | Description |
|---|---|
| Definition | protein tyrosine kinase 6 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:02:00 | Targeting protein tyrosine kinase 6 in cancer. | 32956764 |
| 2020-05-30 10:07:00 | BRK competitively binds and phosphorylates SMAD4 and regulates transforming growth factor-beta/SMAD4 signaling pathway. Activated BRK-mediated degradation of SMAD4 is associated with the repression of tumor suppressor gene FRK and increased expression of mesenchymal markers, SNAIL, and SLUG. | 31681835 |
| 2020-04-04 10:07:00 | PSPC1, a nuclear substrate of PTK6, sequesters PTK6 in the nucleus and loses its metastasis driving capability in hepatocellular carcinoma. Conversely, PSPC1 upregulation or PSPC1-Y523F mutation promotes epithelial-mesenchymal transition, stemness, and metastasis via cytoplasmic translocation of active PTK6 and nuclear translocation of beta-catenin, which interacts with PSPC1 to augment Wnt3a autocrine signaling. | 31844057 |
| 2020-03-28 11:53:00 | Using saturation transfer difference NMR and molecular docking, we demonstrate that vemurafenib binds in the active site of PTK6, inhibiting its activation. These structural studies provide insight into the PTK6-vemurafenib complex, which can be utilized for further refinement chemistry, whereas functional studies demonstrate that active PTK6 is a viable drug target in prostate cancer | 30926642 |
| 2019-05-04 10:14:00 | Study provides evidence that BRK is regulated by ERalpha signaling in ER-positive breast cancer cells. Overall survival of ER-positive breast cancer patients is poor when their cancers express high levels of BRK. These data indicate that BRK is a prognostic marker for ER+ breast cancers. | 30651078 |
| Type | IDs |
|---|---|
| Synonymous | BRK |
| Gene |
UniProtKB-ID:
PTK6_HUMAN
UniprotKB:
Q13882
UniParc:
UPI000004F1D9,
UPI0002374A42
EMBL:
AK315232,
U61411,
U61406,
U61407,
AL121829,
U61409,
X78549,
AK301364,
U61408,
BC035843,
U61412,
U61410
Ensembl:
ENSG00000101213
KO:
hsa:5753
|
| Nucleutide sequences |
EMBL-CDS:
AAC34935.1,
AAH35843.1,
BAG37660.1,
CAA55295.1,
BAG62908.1
Ensembl_TRS:
ENST00000542869,
ENST00000217185
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000217185,
ENSP00000442460
RefSeq:
XP_016883471.1,
NP_005966.1,
NP_001243287.1
|
| Others |
UniRef100:
UniRef100_Q13882
UniRef90:
UniRef90_Q13882
UniRef50:
UniRef50_Q13882
UniGene:
Hs.51133
CCDS:
CCDS74750.1,
CCDS13524.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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