| Type | Description |
|---|---|
| Definition | LYN proto-oncogene, Src family tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:54:00 | Erlotinib is effective against FLT3-ITD mutant AML and helps to overcome intratumoral heterogeneity via targeting FLT3 and Lyn. | 32543003 |
| 2020-09-19 16:30:00 | Lyn regulates creatine uptake in an imatinib-resistant CML cell line. | 31881245 |
| 2020-07-18 12:23:00 | Upon BCR activation, Lyn, Syk and ZAP-70 recruitment into lipid rafts (LR) increased significantly in B cells of healthy controls and patients with inactive Systemic Lupus Erythematosus (SLE). In active SLE patients there was a great heterogeneity in the recruitment of signaling molecules and the recruitment of ZAP-70 was mainly observed in patients with decreased Syk recruitment into LR of activated B cells. | 30840855 |
| 2020-05-09 11:15:00 | Hematopoietic cell-specific Lyn substrate, HCLS1, is a versatile actin-binding protein in leukocytes. (Review) | 30537294 |
| 2020-03-07 11:39:00 | Lyn expression was up-regulated in COPD-smoker patients. | 31477108 |
| Type | IDs |
|---|---|
| Synonymous | JTK8, p53Lyn, p56Lyn |
| Gene |
UniProtKB-ID:
LYN_HUMAN,
Q6NUK7_HUMAN,
A8K379_HUMAN
UniprotKB:
P07948,
Q6NUK7,
A8K379
UniParc:
UPI00015DA742,
UPI000016AC37,
UPI000013DACD,
UPI00001D6EFD
EMBL:
BC068551,
M79321,
BC126458,
AK290494,
BC075001,
M16038,
BC126456,
BC075002,
BC059394
Ensembl:
ENSG00000254087
KO:
hsa:4067
|
| Nucleutide sequences |
EMBL-CDS:
AAA59540.1,
AAB50019.1,
AAH75001.1,
AAI26457.1,
AAH75002.1,
AAI26459.1,
AAH68551.1,
AAH59394.1,
BAF83183.1
Ensembl_TRS:
ENST00000519728,
ENST00000520220
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000428424,
ENSP00000428924
RefSeq:
XP_016868905.1,
XP_016868904.1,
XP_011515831.1,
NP_002341.1,
NP_001104567.1
|
| Others |
UniRef100:
UniRef100_P07948,
UniRef100_A8K379,
UniRef100_K7AHF5
UniRef90:
UniRef90_A8K379,
UniRef90_A0A2U4AJ04,
UniRef90_P07948
UniRef50:
UniRef50_Q07014-2,
UniRef50_P08631
UniGene:
Hs.491767,
Hs.545418
CCDS:
CCDS47859.1,
CCDS6162.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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