The iPLA(2)γ is identified as the membrane potential sensitive phospholipase in liver mitochondria.
FEBS Lett.2015 Aug 19;589(18):2367-71. Epub 2015 Jul 20
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摘要
Previous reports from our lab identified a mitochondrial calcium-independent phospholipase A2 activity that is activated when the mitochondrial membrane potential is decreased. This activity was demonstrated to influence occurrence of the permeability transition. Originally, this activity was ascribed to the iPLA2β protein. Recently, both iPLA2β and iPLA2γ knock out mice have been generated. It has been shown by others that the iPLA2γ plays a significant role in progression of the permeability transition. In this paper, using the iPLA2β and iPLA2γ knock out mice we show that the membrane potential sensitive activity is the iPLA2γ.
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基因功能
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原始数据
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文献解读
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