Pla2g6 - phospholipase A2, group VI-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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53357 Pla2g6

基因描述

Type	Description
Definition	phospholipase A2, group VI

研究结论

Date	Results	Publications
2021-01-23 13:03:00	Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages.	33177235
2020-05-16 11:14:00	This study provides insights into iPla2b (PLA2G6) inactivation for injury susceptibility under normal conditions and liver fibrosis and cholangiopathies during methionine-choline-deficient diet feeding.	31409057
2020-04-18 10:07:00	the regulation of iPLA2beta/Cardiolipin/Opa1 by HGSD may prevent beta-cell apoptosis and may improve islet beta-cell function in Type 2 diabetic mice and in palmitate-treated MIN6 cells	31337982
2019-12-07 11:43:00	iPLA2beta-KO mice were protected from hepatic steatosis after chronic but not short-term high-fat-diet.	30735855
2019-12-07 11:43:00	iPLA2beta inactivation did not alter hepatic phospholipids in methionine- and choline-deficient - induced lean non-alcoholic steatohepatitis.	30735854

名称对应

Type	IDs
Synonymous	BB112799, PNPLA9, iPLA(2)beta, iPLA2, iPLA2beta
Gene	UniProtKB-ID: PLPL9_MOUSE, Q3UN31_MOUSE, Q3U613_MOUSE UniprotKB: P97819, Q3UN31, Q3U613 UniParc: UPI000002896D, UPI00005ACC9D, UPI0000029648 EMBL: AK153333, AF259401, U88624, BC057209, BC003487, AK144495 Ensembl: ENSMUSG00000042632 KO: mmu:53357
Nucleutide sequences	EMBL-CDS: AAH57209.1, AAB48511.2, AAH03487.1, AAF72651.1, BAE25917.1, BAE31912.1 Ensembl_TRS: ENSMUST00000166977, ENSMUST00000047816, ENSMUST00000174021, ENSMUST00000173163, ENSMUST00000172403
Protein sequencees	Ensembl_PRO: ENSMUSP00000044234, ENSMUSP00000134672, ENSMUSP00000131081, ENSMUSP00000134456, ENSMUSP00000132071 RefSeq: XP_036015409.1, XP_036015406.1, XP_036015397.1, XP_036015399.1, XP_036015407.1, XP_006521219.1, XP_006521218.1, XP_017172187.1, XP_036015400.1, XP_036015405.1, XP_036015396.1, XP_006521222.1, XP_036015403.1, NP_001185952.1, NP_001185953.1, XP_036015411.1, XP_036015410.1, XP_036015401.1, XP_036015402.1, XP_030104517.1, NP_001185954.1, XP_036015398.1, XP_036015408.1, XP_006521216.1, NP_058611.1, XP_036015404.1
Others	UniRef100: UniRef100_Q3U613, UniRef100_Q3UN31, UniRef100_P97819 UniRef90: UniRef90_A0A3L7I2I8-2, UniRef90_P97570 UniRef50: UniRef50_A0A3L7I2I8-2, UniRef50_O60733-2 UniGene: Mm.155620 CCDS: CCDS27637.1, CCDS56991.1

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mRNA

Protein

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Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
33177235	Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages. Proc Natl Acad Sci U S A Ajay Suresh Akhade , Shaikh M Atif , Bhavana S Lakshmi , Neha Dikshit , Kelly T Hughes , Ayub Qadri , Naeha Subramanian	2020-11-24	-
33087576	PLA2G6 guards placental trophoblasts against ferroptotic injury. Proc Natl Acad Sci U S A Ofer Beharier , Vladimir A Tyurin , Julie P Goff , Jennifer Guerrero-Santoro , Kazuhiro Kajiwara , Tianjiao Chu , Yulia Y Tyurina , Claudette M St Croix , Callen T Wallace , Samuel Parry , W Tony Parks , Valerian E Kagan , Yoel Sadovsky	2020-11-03	-
33080873	Metabolic Effects of Selective Deletion of Group VIA Phospholipase A₂ from Macrophages or Pancreatic Islet Beta-Cells. Biomolecules John Turk , Haowei Song , Mary Wohltmann , Cheryl Frankfater , Xiaoyong Lei , Sasanka Ramanadham	2020-10-17	-
32325033	BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili	2020-04-22	-
31409057	iPla2Î² Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation. Cells Yanan Ming , Xingya Zhu , Sabine Tuma-Kellner , Alexandra Ganzha , Gerhard Liebisch , Hongying Gan-Schreier , Walee Chamulitrat	2019-08-12	-
30088174	PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Mol Neurobiol Ching-Chi Chiu , Chin-Song Lu , Yi-Hsin Weng , Ying-Ling Chen , Ying-Zu Huang , Rou-Shayn Chen , Yi-Chuan Cheng , Yin-Cheng Huang , Yu-Chuan Liu , Szu-Chia Lai , Kun-Jun Lin , Yan-Wei Lin , Yu-Jie Chen , Chao-Lang Chen , Tu-Hsueh Yeh , Hung-Li Wang	2019-06-01	-
30735855	Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. Biochim Biophys Acta Mol Cell Biol Lipids Ann-Christin Otto , Hongying Gan-Schreier , Xingya Zhu , Sabine Tuma-Kellner , Simone Staffer , Alexandra Ganzha , Gerhard Liebisch , Walee Chamulitrat	2019-05-01	-
30735854	iPla2Î² deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes. Biochim Biophys Acta Mol Cell Biol Lipids Xingya Zhu , Hongying Gan-Schreier , Ann-Christin Otto , Yuting Cheng , Simone Staffer , Sabine Tuma-Kellner , Alexandra Ganzha , Gerhard Liebisch , Walee Chamulitrat	2019-05-01	-
31337982	Amorphous solid dispersion of Berberine mitigates apoptosis via iPLA₂Î²/Cardiolipin/Opa1 pathway in db/db mice and in Palmitate-treated MIN6 Î²-cells. Int J Biol Sci Junnan Li , Hongwei Du , Meishuang Zhang , Zhi Zhang , Fei Teng , Yali Zhao , Wenyou Zhang , Yang Yu , Linjing Feng , Xinming Cui , Ming Zhang , Tzongshi Lu , Fengying Guan , Li Chen	2019-01-01	-
28888832	Ageing sensitized by iPLA2Î² deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids. Biochim. Biophys. Acta Li Jiao , Hongying Gan-Schreier , Xingya Zhu , Wang Wei , Sabine Tuma-Kellner , Gerhard Liebisch , Wolfgang Stremmel , Walee Chamulitrat	2017-12-01	-

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