mcrC - 5-methylcytosine-specific restriction enzyme subunit McrC-BMKCloudï½ç¾è¿å®¢äº

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948880 mcrC

基因描述

Type	Description
Definition	5-methylcytosine-specific restriction enzyme subunit McrC

研究结论

Date	Results	Publications
2019-10-26 11:10:00	Study present the structure of the AAA+ domain of Escherichia coli McrB in complex with McrC at 3.6 A resolution using cryo-electron microscopy, which reveals the coupling between the endonuclease and the motor and the mechanism of activation of the GTPase.	31296862
2007-11-05 21:38:00	N-terminus verified by Edman degradation on complete protein	2050643

名称对应

Type	IDs
Synonymous	ECK4335
Gene	UniProtKB-ID: MCRC_ECOLI UniprotKB: P15006 UniParc: UPI000012EDC5 EMBL: U14003, M58752, M24927, AP009048, U00096 EnsemblGenome: BAE78335, b4345 KO: ecj:JW5789, eco:b4345
Nucleutide sequences	EMBL-CDS: AAC77301.1, AAA24144.1, AAA97242.1, AAA24146.1, BAE78335.1 EnsemblGenome_TRS: BAE78335, AAC77301
Protein sequencees	EnsemblGenome_PRO: BAE78335, AAC77301 RefSeq: NP_418765.1
Others	UniRef100: UniRef100_P15006 UniRef90: UniRef90_P15006 UniRef50: UniRef50_P15006

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Pubmed编号	文献信息	发表日期	相关基因
31296862	Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC. Nat Commun Neha Nirwan , Yuzuru Itoh , Pratima Singh , Sutirtha Bandyopadhyay , Kutti R Vinothkumar , Alexey Amunts , Kayarat Saikrishnan	2019-07-11	-
19025584	Cell death upon epigenetic genome methylation: a novel function of methyl-specific deoxyribonucleases. Genome Biol Eri Fukuda , Katarzyna H Kaminska , Janusz M Bujnicki , Ichizo Kobayashi	2008-01-01	-
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
11955074	The GTP-dependent restriction enzyme McrBC from Escherichia coli forms high-molecular mass complexes with DNA and produces a cleavage pattern with a characteristic 10-base pair repeat. Biochemistry Uwe Pieper , Detlef H Groll , Sandra WÃ¼nsch , Frank-Ulrich Gast , Christian Speck , Norbert MÃ¼cke , Alfred Pingoud	2002-04-23	-
11955073	A mutational analysis of the PD...D/EXK motif suggests that McrC harbors the catalytic center for DNA cleavage by the GTP-dependent restriction enzyme McrBC from Escherichia coli. Biochemistry Uwe Pieper , Alfred Pingoud	2002-04-23	-
11872734	Lack of regulation of the modification-dependent restriction enzyme McrBC in Escherichia coli. J Bacteriol Mark Murphy , Stefanie Schmid Nuoffer , Thomas A Bickle	2002-03-01	-
11406597	The McrBC restriction endonuclease assembles into a ring structure in the presence of G nucleotides. EMBO J. D Panne , S A MÃ¼ller , S Wirtz , A Engel , T A Bickle	2001-06-15	mcrC, mcrB
11200231	Grouping together highly diverged PD-(D/E)XK nucleases and identification of novel superfamily members using structure-guided alignment of sequence profiles. J. Mol. Microbiol. Biotechnol. J M Bujnicki , L Rychlewski	2001-01-01	mcrC, mcrB
10788324	Methyl-specific DNA binding by McrBC, a modification-dependent restriction enzyme. J. Mol. Biol. F J Stewart , D Panne , T A Bickle , E A Raleigh	2000-05-12	mcrC, mcrB

研究热度

该基因近6年没有文献发表

热点单位

排名	科研单位	文献
1	Institut für Biochemie	3
2	New England Biolabs, Beverly, Massachusetts 01915.	3
3	Basel University	2
4	Louisiana State University	2
5	Institut für Biochemie (FB 08)	2

热点人员

排名	研究人员	文献
1	E A Raleigh	12
2	T A Bickle	4
3	D Panne	4
4	U Pieper	4
5	A Pingoud	4

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