| Type | Description |
|---|---|
| Definition | zygote arrest 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:02:00 | The ZAR1 protein in cancer; from epigenetic silencing to functional characterisation and epigenetic therapy of tumour suppressors. | 32828887 |
| 2020-12-19 13:39:00 | Variation Screening of Zygote Arrest 1(ZAR1) in Women with Recurrent Zygote Arrest During IVF/ICSI Programs. | 32700283 |
| 2020-07-25 12:50:00 | Study presents evidence that ZAR1, which harbors tumor suppressive properties, is a prognostic and diagnostic cancer biomarker for lung and kidney. ZAR1 suppresses tumor cell line growth in part through p53 and strongly depending on its functional zinc-finger. | 31801617 |
| 2018-05-19 11:47:00 | ZAR1 has oncogenic effects in neuroblastoma by suppressing cell differentiation via regulation of MYCN expression.Elevated ZAR1 expression level is closely related to poor prognosis of patients with neuroblastoma. | 28791558 |
| 2018-04-21 11:27:00 | Study shows for the first time the lung tumor-specific epigenetic inactivation of ZAR1 due to DNA methylation of its CpG island promoter. Furthermore, ZAR1 was characterized by the ability to block tumor growth through the inhibition of cell cycle progression in cancer cell lines. | 28588743 |
| Type | IDs |
|---|---|
| Synonymous | Z3CXXC6 |
| Gene |
UniProtKB-ID:
ZAR1_HUMAN,
B9EG67_HUMAN
UniprotKB:
Q86SH2,
B9EG67
UniParc:
UPI000192C3DE,
UPI000000D8B4
EMBL:
BC136265,
AY193890,
AY191416
Ensembl:
ENSG00000182223
KO:
hsa:326340
|
| Nucleutide sequences |
EMBL-CDS:
AAO24709.1,
AAO24707.1,
AAI36266.1
Ensembl_TRS:
ENST00000327939
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000329803
RefSeq:
NP_783318.1
|
| Others |
UniRef100:
UniRef100_B9EG67,
UniRef100_Q86SH2
UniRef90:
UniRef90_Q86SH2
UniRef50:
UniRef50_Q86SH2
UniGene:
Hs.276457
CCDS:
CCDS3483.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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