ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer.
[No authors listed]
摘要
BACKGROUND:Lung cancer is the leading cause of cancer-related deaths with 1.8 million new cases each year and poor 5-year prognosis. Promoter hypermethylation of tumour suppressors leads to their inactivation and thereby can promote cancer development and progression. RESULTS: not only inhibited colony formation but also blocked cell cycle progression of cancer cell lines. CONCLUSIONS: due to DNA methylation of its CpG island promoter. Furthermore, ZAR1 was characterised by the ability to block tumour growth through the inhibition of cell cycle progression in cancer cell lines. We propose that ZAR1 could serve as an epigenetically inactivated biomarker in lung cancer.
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基因功能
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原始数据
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文献解读
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