| Type | Description |
|---|---|
| Definition | glutamate metabotropic receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:55:00 | This study provided the evidence that glutamate causes a dose-dependent increase in [Ca2+]i by activating mGluR1 and, at a larger extent, mGluR5. | 31473770 |
| 2020-02-15 11:55:00 | we report the third pathogenic variant in GRM1 gene causing an autosomal-recessive form of cerebellar ataxia. Our observation not only emphasizes the central role of mGluR1-mediated signaling in cerebellar function but also provides valuable insights into the early clinical signs of recessive ataxia due to biallelic GRM1 pathogenic variants. | 31319223 |
| 2019-12-21 11:00:00 | TRPC6 regulates actin stress fiber formation and focal adhesions via the RhoA pathway in response to group I metabotropic glutamate receptor activation. | 30782481 |
| 2019-10-26 11:31:00 | Our results suggest mGluR1 may serve as a novel endogenous regulator of inflammation in triple negative breast cancer. | 30375476 |
| 2018-09-22 10:45:00 | Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling. | 28948209 |
| Type | IDs |
|---|---|
| Synonymous | GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13 |
| Gene |
UniProtKB-ID:
GRM1_HUMAN,
Q59HC2_HUMAN
UniprotKB:
Q13255,
Q59HC2
UniParc:
UPI000016AC16,
UPI000013DCFD,
UPI0001D3BCBF,
UPI00004F6A81
EMBL:
BC143779,
U31215,
U31216,
L76627,
AL035698,
BC136280,
AL592423,
L76631,
AL096867,
AB208837,
AL031769
Ensembl:
ENSG00000152822
KO:
hsa:2911
|
| Nucleutide sequences |
EMBL-CDS:
AAB05338.1,
AAA87843.1,
AAI36281.1,
AAA87844.1,
AAB05337.1,
BAD92074.1
Ensembl_TRS:
ENST00000507907,
ENST00000361719,
ENST00000355289,
ENST00000282753,
ENST00000492807
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000425599,
ENSP00000347437,
ENSP00000424095,
ENSP00000282753,
ENSP00000354896
RefSeq:
NP_001264994.1,
NP_001264993.1,
XP_016866275.1,
XP_016866276.1,
XP_011534084.1,
NP_001264996.1,
XP_024302180.1,
XP_016866273.1,
XP_016866274.1,
XP_016866277.1,
XP_016866272.1,
NP_001264995.1
|
| Others |
UniRef100:
UniRef100_Q59HC2,
UniRef100_Q13255
UniRef90:
UniRef90_P23385,
UniRef90_P23385-2
UniRef50:
UniRef50_P23385-2,
UniRef50_P23385
UniGene:
Hs.32945
CCDS:
CCDS47497.1,
CCDS5209.1,
CCDS64548.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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