Age and gender effects of ¹¹C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants.

We examined possible age- and gender-related changes in binding of the selective antagonist N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-¹¹C-methoxy-N-methylbenzamide (¹¹C-ITMM) to metabotropic glutamate receptor type 1 in healthy human brains. Dynamic ¹¹C-ITMM positron emission tomography scans (90 min) with serial arterial blood sampling were performed in 15 young and 24 older healthy adult volunteers. The total distribution volume (V_T) of several brain regions was estimated with 2-tissue compartment model analysis. The V_Ts of the cerebellar cortex, parietal cortex, putamen, amygdala, and hippocampus in older adult participants were significantly higher than in young participants. The age-related V_T increase was only observed in male participants. Our data suggest that an age-dependent increase in metabotropic glutamate receptor type 1 availability in several brain regions may exist predominantly in males.

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