p85Î² phosphoinositide 3-kinase subunit regulates tumor progression.

Proc. Natl. Acad. Sci. U.S.A.2012 Jul 10;109(28):11318-23. Epub 2012 Jun 25

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PIK3R2 encodes a ubiquitous regulatory subunit (p85Î²) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and migration. We found that p85Î² expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K pathway activation and tumor progression. p85Î² expression induced moderate PIP(3) generation at the cell membrane and enhanced cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor progression in vivo. Increased p85Î² expression thus represents a cellular strategy in cancer progression.

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p85Î² phosphoinositide 3-kinase subunit regulates tumor progression.

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