Mediator and post-recruitment regulation of RNA polymerase II.

Transcription. 2011 Jan-Feb ;2(1):28-31. doi:10.4161/trns.2.1.13950

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摘要

The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.

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Mediator and post-recruitment regulation of RNA polymerase II.

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