Midline crossing and Slit responsiveness of commissural axons require USP33.
Nat. Neurosci.2009 Sep;12(9):1087-9. Epub 2009 Aug 16
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摘要
Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.
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基因功能
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原始数据
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文献解读
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