mdtM - multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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948861 mdtM

基因描述

Type	Description
Definition	multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter

研究结论

Date	Results	Publications
2018-11-10 12:11:00	MdtM, a 410 amino acid residue protein that belongs to the large and ubiquitous major facilitator superfamily. [review]	28962921
2016-06-28 11:43:00	The yjiL-mdtM gene cluster mediates the antibacterial activity of proline-rich antimicrobial peptides overcoming Escherichia coli resistance induced by the missing SbmA transporter system.	26169420
2014-12-27 11:28:00	MdtM, a single-component multidrug resistance transporter of the major facilitator superfamily, functions in bile salt resistance in Escherichia coli by catalysing secondary active transport of bile salts out of the cell cytoplasm.	24684269
2013-10-26 10:59:00	Taken together, the results support a role for MdtM in alkaline pH tolerance. MdtM can therefore be added to the currently limited list of antiporters known to function in pH homeostasis in the model organism E. coli.	23701827
2012-09-01 11:22:00	Purified MdtM is monomeric and stable in dodecyl-beta-D-maltopyranoside solution and binds chloramphenicol with nanomolar affinity in the same detergent.	22426385

名称对应

Type	IDs
Synonymous	ECK4328, yjiO
Gene	UniProtKB-ID: MDTM_ECOLI UniprotKB: P39386 UniParc: UPI000013B5B7 EMBL: AP009048, U14003, U00096, AY283773 EnsemblGenome: b4337, BAE78330 KO: ecj:JW4300, eco:b4337
Nucleutide sequences	EMBL-CDS: AAC77293.1, AAP43530.1, AAA97233.1, BAE78330.1 EnsemblGenome_TRS: AAC77293, BAE78330
Protein sequencees	EnsemblGenome_PRO: AAC77293, BAE78330 RefSeq: NP_418757.1
Others	UniRef100: UniRef100_P39386 UniRef90: UniRef90_P39386 UniRef50: UniRef50_P39386

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
28962921	Clamping down on drugs: the Escherichia coli multidrug efflux protein MdtM. Res. Microbiol. Christopher J Law , Kamela O Alegre	2017-09-27	-
26169420	Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System. Antimicrob. Agents Chemother. Andor Krizsan , Daniel Knappe , Ralf Hoffmann	2015-10-01	-
24684269	A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress. Mol. Microbiol. Stephanie Paul , Kamela O Alegre , Scarlett R Holdsworth , Matthew Rice , James A Brown , Paul McVeigh , Sharon M Kelly , Christopher J Law	2014-05-01	mdtM
23701827	Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli. BMC Microbiol. Scarlett R Holdsworth , Christopher J Law	2013-05-23	-
22426385	Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM. Biochimie Scarlett R Holdsworth , Christopher J Law	2012-06-01	mdtM
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
19451626	A coordinated network of transporters with overlapping specificities provides a robust survival strategy. Proc. Natl. Acad. Sci. U.S.A. Nir Tal , Shimon Schuldiner	2009-06-02	acrB, acrA, mdfA, tolC, emrE, mdtM
16842212	Microbial drug efflux proteins of the major facilitator superfamily. Curr Drug Targets Massoud Saidijam , Giulia Benedetti , Qinghu Ren , Zhiqiang Xu , Christopher J Hoyle , Sarah L Palmer , Alison Ward , Kim E Bettaney , Gerda Szakonyi , Johan Meuller , Scott Morrison , Martin K Pos , Patrick Butaye , Karl Walravens , Kate Langton , Richard B Herbert , Ronald A Skurray , Ian T Paulsen , John O'reilly , Nicholas G Rutherford , Melissa H Brown , Roslyn M Bill , Peter J F Henderson	2006-07-01	-
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM

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