uhpT - hexose-6-phosphate:phosphate antiporter-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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948201 uhpT

基因描述

Type	Description
Definition	hexose-6-phosphate:phosphate antiporter

研究结论

Date	Results	Publications
2019-06-01 10:15:00	Fosfomycin resistant E. coli mutants contain the deletion of uhpT encoding hexose-6-phosphate antiporter or a nonsense mutation in DNA-binding transcriptional activator UhpA (uhpA). The expression of uhpT is absent in the mutant strains with uhpT deletion and is not inducible in the strain with the uhpA mutation. The mutants have reduced growth on minimal medium supplemented with glucose-6-phosphate.	29093108
2017-02-25 10:06:00	eduction of uhpT function is largely responsible for the reduced sensitivity to FOM in clinical isolates that have not acquired FOM-modifying genes or mutations in murA.	28197413
2016-06-28 10:13:00	Elevated expression of GlpT and UhpT via FNR activation contributes to increased fosfomycin susceptibility in Escherichia coli under anaerobic conditions.	26248376
2010-01-21 00:00:00	the Asp388-Lys391 ion pair acts normally as a filter that prevents substrates lacking a proton that can be donated from occupying the UhpT active site.	15556940

名称对应

Type	IDs
Synonymous	ECK3657
Gene	UniProtKB-ID: UHPT_ECOLI UniprotKB: P0AGC0 UniParc: UPI0000137B21 EMBL: U00096, AP009048, M89479, L10328, M17102 EnsemblGenome: BAE77627, b3666 KO: ecj:JW3641, eco:b3666
Nucleutide sequences	EMBL-CDS: AAC76689.1, BAE77627.1, AAA24727.1, AAA24723.1, AAA62018.1 EnsemblGenome_TRS: BAE77627, AAC76689
Protein sequencees	EnsemblGenome_PRO: BAE77627, AAC76689 RefSeq: NP_418122.1
Others	UniRef100: UniRef100_P0AGC1 UniRef90: UniRef90_P0AGC1 UniRef50: UniRef50_P27670

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
29093108	Frequency and Mechanisms of Spontaneous Fosfomycin Nonsusceptibility Observed upon Disk Diffusion Testing of Escherichia coli. J. Clin. Microbiol. Aaron E Lucas , Ryota Ito , Mustapha M Mustapha , Christi L McElheny , Roberta T Mettus , Sarah L Bowler , Serena F Kantz , Marissa P Pacey , A William Pasculle , Vaughn S Cooper , Yohei Doi	2018-01-01	-
28197413	Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates. Biomed Res Int Yasuo Ohkoshi , Toyotaka Sato , Yuuki Suzuki , Soh Yamamoto , Tsukasa Shiraishi , Noriko Ogasawara , Shin-Ichi Yokota	2017-01-01	-
26248376	Elevated Expression of GlpT and UhpT via FNR Activation Contributes to Increased Fosfomycin Susceptibility in Escherichia coli under Anaerobic Conditions. Antimicrob. Agents Chemother. Kumiko Kurabayashi , Koichi Tanimoto , Shinobu Fueki , Haruyoshi Tomita , Hidetada Hirakawa	2015-10-01	-
18593213	Group II intron protein localization and insertion sites are affected by polyphosphate. PLoS Biol. Junhua Zhao , Wei Niu , Jun Yao , Sabine Mohr , Edward M Marcotte , Alan M Lambowitz	2008-06-24	ynbC, wcaK, xapR, ppx, ppk, relA, zntR, spoT, uhpT, gpp
16842212	Microbial drug efflux proteins of the major facilitator superfamily. Curr Drug Targets Massoud Saidijam , Giulia Benedetti , Qinghu Ren , Zhiqiang Xu , Christopher J Hoyle , Sarah L Palmer , Alison Ward , Kim E Bettaney , Gerda Szakonyi , Johan Meuller , Scott Morrison , Martin K Pos , Patrick Butaye , Karl Walravens , Kate Langton , Richard B Herbert , Ronald A Skurray , Ian T Paulsen , John O'reilly , Nicholas G Rutherford , Melissa H Brown , Roslyn M Bill , Peter J F Henderson	2006-07-01	-
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
16381841	TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res. Milton H Saier , Can V Tran , Ravi D Barabote	2006-01-01	ygaY, ecnB, cysW, hokC, nirC, dnaK, nhaA, caiT, yaaU, kefF, kefC, thiP, thiQ, satP, setA, ydfJ, bcr, uidC, secA, nhaB, fhuA, glnH, caiC, metQ, metI, metN, cyoD, phoE, yagG, yahN, codB, mhpT, dcuC, pal, lptD, tauC, tauB, tauA, yajR, cyoE, betT, cyoA, amtB, ftsK, acrB, acrA, fsr, mscK, nuoN, fetB, macB, wbbH, cusF, cusB, cusA, fepA, pheP, fepC, fepG, cstA, fepD, tatE, mrdB, fhuC, gltL, ynfF, nagE, tolR, chbB, zitB, mngA, modB, modC, modA, yajC, ybhL, lsrB, exbB, potE, tolB, glnQ, gltJ, mdfA, gsiA, gsiB, gsiC, gsiD, acrD, ybjJ, potH, potG, potF, potI, artP, aqpZ, dmsC, cydC, dmsB, dmsA
16120447	Experimentally constrained topology models for 51,208 bacterial inner membrane proteins. J. Mol. Biol. Erik Granseth , Daniel O Daley , Mikaela Rapp , Karin MelÃ©n , Gunnar von Heijne	2005-09-23	arnE, ygaY, glvC, yfjD, cysW, ghxQ, nirC, gntU, yrdE, nhaA, yaaU, kefC, yabI, satP, setA, lspA, yfdC, ydfJ, bcr, mraY, wzzE, gcd, yadH, cdsA, metI, cyoD, yciS, yagG, yahN, rclC, codB, mhpT, pqiA, dcuC, tauC, yqeG, gfcA, brnQ, phoR, proY, cvpA, yajR, cyoE, cyoA, amtB, mdlB, mdlA, ygaZ, ftsK, acrB, fsr, ybbJ, ybbY, mscK, nuoN, fetB, ybbW, ybcI, ydgC, ydgI, fepE, cusA, yedE, pheP, fepG, cstA, fepD, yaiY, citA, mrdB, sapC, arnC, nagE, hyfE, aer, sdhC, sdhD, lptG, cydA, arnF, cydB, zitB, pnuC, mngA, opgE, modB, ybaT, ybhI, yifK, ybhL, ybhR, ybhQ, ybhN, ybhS, yqaA, exbB, potE, ybiR, gltJ
15919996	Global topology analysis of the Escherichia coli inner membrane proteome. Science Daniel O Daley , Mikaela Rapp , Erik Granseth , Karin MelÃ©n , David Drew , Gunnar von Heijne	2005-05-27	arnE, wecF, ygaY, glvC, yfjD, cysW, ghxQ, nirC, gntU, yrdE, yaaJ, nhaA, caiT, yaaU, kefC, yabI, thiP, satP, setA, lspA, yfdC, ydfJ, bcr, mraY, wzzE, nhaB, gcd, yadH, rseP, cdsA, metI, cyoD, yciS, yagG, yahN, rclC, eutH, codB, mhpT, pqiA, dcuC, tauC, yqeG, gfcA, brnQ, phoR, proY, cvpA, yajR, cyoE, betT, cyoA, amtB, mdlB, mdlA, ygaZ, ftsK, acrB, ygaH, ybbP, fsr, ybbJ, ybbY, mscK, nuoN, fetB, ybbW, yniB, ybcI, ydgC, ydgI, macB, wbbH, fepE, cusA, yedE, pheP, fepG, cstA, fepD, yaiY, citA, mrdB, cmtA, sapC, arnC, nagE, hyfE, aer, sdhC, abrB, sdhD, lptG, hycC, cydA, arnF, cydB, zitB, pnuC

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