panZ - PanD maturation factor-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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947963 panZ

基因描述

Type	Description
Definition	PanD maturation factor

研究结论

Date	Results	Publications
2017-10-07 11:44:00	Most vitamin biosynthetic pathways in bacteria are tightly regulated. Data suggest binding of panZ/AcCoA complex to panD regulates pantothenate biosynthesis; this multimerization leads to sequestration of pyruvoyl cofactor as ketone hydrate and activation of panD; antimetabolite N-pentyl-pantothenamide inhibits panD. (panD = aspartate-alpha-decarboxylase; panZ = panD autocleavage accelerator; AcCoA = acetyl coenzyme A)	28832133

名称对应

Type	IDs
Synonymous	ECK3443, livL, panM, yhhK
Gene	UniProtKB-ID: PANZ_ECOLI UniprotKB: P37613 UniParc: UPI000013B24D EMBL: U00096, AP009048, U00039 EnsemblGenome: b3459, BAE77834 KO: ecj:JW3424, eco:b3459
Nucleutide sequences	EMBL-CDS: AAB18434.1, AAC76484.1, BAE77834.1 EnsemblGenome_TRS: BAE77834, AAC76484
Protein sequencees	EnsemblGenome_PRO: AAC76484, BAE77834 RefSeq: NP_417916.1
Others	UniRef100: UniRef100_P37613 UniRef90: UniRef90_P37613 UniRef50: UniRef50_P37613

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
28832133	The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZÂ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan). Biochemistry Zoe L P Arnott , Shingo Nozaki , Diana C F Monteiro , Holly E Morgan , Arwen R Pearson , Hironori Niki , Michael E Webb	2017-09-19	-
25910242	The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. Chem. Biol. Diana C F Monteiro , Vijay Patel , Christopher P Bartlett , Shingo Nozaki , Thomas D Grant , James A Gowdy , Gary S Thompson , Arnout P Kalverda , Edward H Snell , Hironori Niki , Arwen R Pearson , Michael E Webb	2015-04-23	-
22940551	Formation of a heterooctameric complex between aspartate Î±-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent. Biochem. Biophys. Res. Commun. Diana C F Monteiro , Michael D Rugen , Dale Shepherd , Shingo Nozaki , Hironori Niki , Michael E Webb	2012-09-28	-
23170229	An activator for pyruvoyl-dependent l-aspartate Î±-decarboxylase is conserved in a small group of the Î³-proteobacteria including Escherichia coli. Microbiologyopen Shingo Nozaki , Michael E Webb , Hironori Niki	2012-09-01	-
22497218	The missing link in coenzyme A biosynthesis: PanM (formerly YhhK), a yeast GCN5 acetyltransferase homologue triggers aspartate decarboxylase (PanD) maturation in Salmonella enterica. Mol. Microbiol. Tara N Stuecker , Kelsey M Hodge , Jorge C Escalante-Semerena	2012-05-01	panD, yhhK
17012394	Experimental and computational assessment of conditionally essential genes in Escherichia coli. J. Bacteriol. Andrew R Joyce , Jennifer L Reed , Aprilfawn White , Robert Edwards , Andrei Osterman , Tomoya Baba , Hirotada Mori , Scott A Lesely , Bernhard Ã Palsson , Sanjay Agarwalla	2006-12-01	carB, leuB, cra, panB, pdxA, panC, proC, leuC, trpD, purK, fes, thrC, serA, gltA, nadA, trpC, serC, aroA, pyrD, leuD, panD, icd, trpB, cysB, pyrC, thrA, trpE, leuL, trpA, aroD, metC, pabB, proB, hisI, hisF, hisA, hisD, hisH, hisG, hisC, hisB, ubiG, proA, pdxB, purF, pdxH, aroC, cysK, ptsI, crr, cysU, cysP, cysA, purC, purM, guaB, iscS, glyA, purL, pdxJ, nadB, pheA, tyrA, pyrF, cysD, cysN, cysC, cysH, cysI, cysJ, argA, lysA, guaA, prfB, ubiH, leuA, thrB, folB, rpsU, folP, glmM, aroE, pabA, aroB, glpD, panM, cysE, pyrE, ilvB, atpA, atpG, atpC, atpF, atpB, atpH, ilvD, ilvC, ilvA, metR
16606699	Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res Mohammad Arifuzzaman , Maki Maeda , Aya Itoh , Kensaku Nishikata , Chiharu Takita , Rintaro Saito , Takeshi Ara , Kenji Nakahigashi , Hsuan-Cheng Huang , Aki Hirai , Kohei Tsuzuki , Seira Nakamura , Mohammad Altaf-Ul-Amin , Taku Oshima , Tomoya Baba , Natsuko Yamamoto , Tomoyo Kawamura , Tomoko Ioka-Nakamichi , Masanari Kitagawa , Masaru Tomita , Shigehiko Kanaya , Chieko Wada , Hirotada Mori	2006-05-01	-
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
15268940	The LIV-I/LS system as a determinant of azaserine sensitivity of Escherichia coli K-12. FEMS Microbiol. Lett. Takashi Koyanagi , Takane Katayama , Hideyuki Suzuki , Hidehiko Kumagai	2004-08-01	aroP, livF, panM, livK, livH, livM, livG, livJ

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