| Type | Description |
|---|---|
| Definition | transketolase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 10:25:00 | Molecular dynamics simulations confirmed that the mutations of TK rigidified the active-site via the correlated network. | 30530661 |
| 2018-04-28 10:03:00 | Report the crystal structure of the S385Y/D469T/R520Q variant, and molecular docking of three substrates. This now supports our original hypothesis that directed-evolution had generated an evolutionary intermediate with divergent binding modes for the three aromatic aldehydes tested. The new active site contained two binding pockets supporting pi-pi stacking interactions, sterically separated by the D469T mutation. | 27767080 |
| 2013-01-12 10:02:00 | In the present study, ppsA and tktA genes were overexpressed in genetically engineered Escherichia coli to enhance the availability of two precursor substrates, phosphoenolpyruvate and erythrose-4-phosphate. | 22791961 |
| 2010-01-21 00:00:00 | An insertion in tktA that gave synthetic growth defects in a ppGpp0 led to the identification of tktB as a transcriptional target of ppGpp. | 18532980 |
| 2010-01-21 00:00:00 | exponential growth-dependent expression mediated by RpoS action | 15968503 |
| Type | IDs |
|---|---|
| Synonymous | ECK2930, tkt |
| Gene |
UniProtKB-ID:
TKT1_ECOLI
UniprotKB:
P27302
UniParc:
UPI00003B25F3
EMBL:
U00096,
X68025,
AP009048,
M32363,
U28377
EnsemblGenome:
b2935,
BAE76998
KO:
eco:b2935,
ecj:JW5478
|
| Nucleutide sequences |
EMBL-CDS:
BAE76998.1,
CAA48166.1,
AAA69102.1,
AAT48155.1
EnsemblGenome_TRS:
AAT48155,
BAE76998
|
| Protein sequencees |
EnsemblGenome_PRO:
AAT48155,
BAE76998
RefSeq:
YP_026188.1
|
| Others |
UniRef100:
UniRef100_P27302
UniRef90:
UniRef90_P27302
UniRef50:
UniRef50_P27302
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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