alaE - L-alanine exporter-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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947147 alaE

基因描述

Type	Description
Definition	L-alanine exporter

研究结论

Date	Results	Publications
2020-02-15 10:04:00	Study provides evidence that the L-alanine exporter AlaE plays a critical role in avoiding a toxic accumulation of L-alanine and functions as the 'safety valve' under potential high L-alanine environments, such as in animal intestines.	31591285
2017-05-06 20:15:00	the gene expression of the alaE is regulated by Lrp in response to intracellular levels of l-alanine, which eventually leads to intracellular homeostasis of l-alanine concentrations	28057466
2017-02-25 11:48:00	Charged amino acid residues (R45 and D84) in the AlaE transmembrane domain play a pivotal role in L-alanine export.	27572251
2016-05-07 12:17:00	These data suggested that the AlaE-mediated l-alanine extrusion was driven by proton motive force.	26073055
2011-09-17 11:04:00	On the basis of these results, the authors concluded that YgaW is likely to be the physiologically most relevant exporter for L-alanine in Escherichia coli and proposed that the gene be redesignated alaE for alanine export.	21531828

名称对应

Type	IDs
Synonymous	ECK2664, ygaW
Gene	UniProtKB-ID: ALAE_ECOLI UniprotKB: P64550 UniParc: UPI000013B01A EMBL: AP009048, U00096 EnsemblGenome: b2670, BAE76781 KO: ecj:JW2645, eco:b2670
Nucleutide sequences	EMBL-CDS: BAE76781.1, AAC75717.1 EnsemblGenome_TRS: AAC75717, BAE76781
Protein sequencees	EnsemblGenome_PRO: BAE76781, AAC75717 RefSeq: NP_417156.1
Others	UniRef100: UniRef100_P64552 UniRef90: UniRef90_P64552 UniRef50: UniRef50_A8ANM6

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31591285	L-Alanine Exporter, AlaE, of Escherichia coli Functions as a Safety Valve to Enhance Survival under Feast Conditions. Int J Mol Sci Satoshi Katsube , Tasuke Ando , Hiroshi Yoneyama	2019-10-07	-
28057466	Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli. J. Biosci. Bioeng. Kohei Ihara , Kazuki Sato , Hatsuhiro Hori , Yumiko Makino , Shuji Shigenobu , Tasuke Ando , Emiko Isogai , Hiroshi Yoneyama	2017-04-01	-
27572251	Impact of charged amino acid substitution in the transmembrane domain of L-alanine exporter, AlaE, of Escherichia coli on the L-alanine export. Arch. Microbiol. Seryoung Kim , Kohei Ihara , Satoshi Katsube , Tasuke Ando , Emiko Isogai , Hiroshi Yoneyama	2017-01-01	-
26073055	Characterization of the l-alanine exporter AlaE of Escherichia coli and its potential role in protecting cells from a toxic-level accumulation of l-alanine and its derivatives. Microbiologyopen Seryoung Kim , Kohei Ihara , Satoshi Katsube , Hatsuhiro Hori , Tasuke Ando , Emiko Isogai , Hiroshi Yoneyama	2015-08-01	alaE
21531828	Inducible L-alanine exporter encoded by the novel gene ygaW (alaE) in Escherichia coli. Appl Environ Microbiol Hatsuhiro Hori , Hiroshi Yoneyama , Ryuta Tobe , Tasuke Ando , Emiko Isogai , Ryoichi Katsumata	2011-06-01	-
19767843	Global responses of Escherichia coli to adverse conditions determined by microarrays and FT-IR spectroscopy. Can. J. Microbiol. Birgitte Moen , Astrid Oust Janbu , Solveig Langsrud , Oyvind Langsrud , Jon L Hobman , Chrystala Constantinidou , Achim Kohler , Knut Rudi	2009-06-01	rmf, ghrA, alaE
17456747	Cell-free complements in vivo expression of the E. coli membrane proteome. Protein Sci. David F Savage , Corey L Anderson , Yaneth Robles-Colmenares , Zachary E Newby , Robert M Stroud	2007-05-01	yabI, satP, lspA, yciS, rclC, gfcA, cvpA, ygaZ, ygaH, ybbJ, fetB, ybcI, ydgC, yaiY, arnF, ybhL, ybhQ, ybjG, ybjM, ybjO, aqpZ, ycaP, elyC, ybaN, yccF, ycdZ, ydjM, yagU, ymfA, ycfZ, ychQ, pgsA, flc, ychE, yciC, pgpB, sieB, yddG, ydcZ, yccA, ydgK, leuE, yciB, ydjX, ydjZ, yeaL, mntP, yebE, yecN, ygiZ, yedR, yafU, lpxT, yfbV, dedA, yfcA, cysZ, yfeZ, zupT, eamB, marC, ygaP, alaE, ygdD, ygdQ, yahC, argO, yggT, pppA, yghB, pgaD, ykgH, pgpA, bacA, plsY, ybfB, ygjV, mreD, mscL, gspO, yhgN, yhhN, uspB, yhiD, hdeD, yiaD, yiaA, yiaW, yibI, yiaB, yicG, yidI, yidH, yidG, cbrB, rhtB, yigF, yigG, yiiR
16397293	Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner	2006-01-01	pmrR, yfaS, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeF, yoeB, yohO, arnE, ypdJ, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, yifN, wecF, yigE, blr, yggP, cpxP, ygaY, hdfR, thiS, yedN, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, glvC, yhaM, tdcG, ytfR, yehH, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, gapC, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, yedS, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yaiX, yoeA, yneM
16738553	Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi	2006-01-01	pmrR, torI, yaeP, ykfH, ykgO, ylcG, rzoD, ybdZ, cydX, gnsA, insA, ymgF, ymiA, yciX, rzoR, ynfO, yniD, yobH, yoeB, yohO, arnE, ypeB, ypfN, ypjJ, arfA, yheV, ysaB, sgcB, yjhX, ytjA, yibT, yicS, yidD, yifL, ghoT, yjjZ, mntS, iroK, wecF, yigE, blr, yggP, cpxP, hdfR, thiS, greB, rtcA, smf, ygcU, ypjK, hokE, sslE, glcF, glcE, yhaM, tdcG, ytfR, hokB, ldrD, hokA, ldrA, ldrB, ecnA, ecnB, yfjD, yhdP, yjjV, cysW, hokC, ghxQ, tatD, yjdP, cutC, nirC, frlC, aroK, gntU, dgoD, dgoA, dgoR, yigL, ldrC, ylbE, ydbJ, yeiW, yehK, yneM, ykfM, ylcI, yciY, yncL, ylcH, ynhF, yciZ, ydgU, ypfM, ymgI, ymgJ, dinQ
15919996	Global topology analysis of the Escherichia coli inner membrane proteome. Science Daniel O Daley , Mikaela Rapp , Erik Granseth , Karin MelÃ©n , David Drew , Gunnar von Heijne	2005-05-27	arnE, wecF, ygaY, glvC, yfjD, cysW, ghxQ, nirC, gntU, yrdE, yaaJ, nhaA, caiT, yaaU, kefC, yabI, thiP, satP, setA, lspA, yfdC, ydfJ, bcr, mraY, wzzE, nhaB, gcd, yadH, rseP, cdsA, metI, cyoD, yciS, yagG, yahN, rclC, eutH, codB, mhpT, pqiA, dcuC, tauC, yqeG, gfcA, brnQ, phoR, proY, cvpA, yajR, cyoE, betT, cyoA, amtB, mdlB, mdlA, ygaZ, ftsK, acrB, ygaH, ybbP, fsr, ybbJ, ybbY, mscK, nuoN, fetB, ybbW, yniB, ybcI, ydgC, ydgI, macB, wbbH, fepE, cusA, yedE, pheP, fepG, cstA, fepD, yaiY, citA, mrdB, cmtA, sapC, arnC, nagE, hyfE, aer, sdhC, abrB, sdhD, lptG, hycC, cydA, arnF, cydB, zitB, pnuC

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