| Type | Description |
|---|---|
| Definition | putative lipid II flippase MurJ |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 10:21:00 | study provides in vivo evidence that MurJ uses an alternating-access mechanism during the lipid II transport cycle. | 30482840 |
| 2019-03-23 11:29:00 | MurJ localizes both in the lateral membrane and at midcell, and is recruited to midcell simultaneously with late-localizing divisome proteins and proteins MraY and MurG. This study visualizes MurJ localization in vivo and reveals a possible mechanism of MurJ recruitment during cell division. | 30112777 |
| 2018-09-08 11:53:00 | The crystal structure of substrate-free MurJ reveals an inward-open conformation. High-throughput mutagenesis and next-generation sequencing assessed mutational tolerance at every amino acid in the protein, providing a detailed functional and structural map for the enzyme and identifying sites for inhibitor development. A rocker-switch model for lipid II transport was supported. | 29891673 |
| 2015-02-21 11:58:00 | From these data, authors hypothesize that some charged residues in the cavity region of MurJ homologs are required for interaction with lipid II and/or energy coupling during transport. | 25225268 |
| 2014-08-09 11:14:00 | MurJ is the lipid II flippase in Escherichia coli. | 25013077 |
| Type | IDs |
|---|---|
| Synonymous | ECK1054, mviN, yceN |
| Gene |
UniProtKB-ID:
MURJ_ECOLI
UniprotKB:
P0AF16
UniParc:
UPI000012FA8B
EMBL:
AP009048,
U00096
EnsemblGenome:
b1069,
BAA35877
KO:
eco:b1069,
ecj:JW1056
|
| Nucleutide sequences |
EMBL-CDS:
BAA35877.1,
AAC74153.1
EnsemblGenome_TRS:
BAA35877,
AAC74153
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA35877,
AAC74153
RefSeq:
NP_415587.1
|
| Others |
UniRef100:
UniRef100_P0AF16
UniRef90:
UniRef90_P0AF16
UniRef50:
UniRef50_P0AF16
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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