| Type | Description |
|---|---|
| Definition | undecaprenyl diphosphate synthase |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 12:24:00 | Here, we report that a mutation altering the UppS enzyme that synthesizes undecaprenyl phosphate prevents cells from growing at high temperatures, and that compensatory mutations in enzymes functioning upstream of UppS can reverse this phenotype | 29986944 |
| 2010-11-27 11:00:00 | Unlike the sequential mechanism used by trans-prenyltransferases, these data demonstrate E. coli UPPS utilizes the concerted mechanism. | 20828539 |
| 2010-01-21 00:00:00 | undecaprenyl pyrophosphate synthase (UPPs)is crystallized in a new trigonal unit cell with Mg(2+)/isopentenyl pyrophosphates (IPP)/farnesyl thiopyrophosphate bound to the active site | 15788389 |
| 2010-01-21 00:00:00 | L85, L88 or F89 are important for substrate binding but not specificity. The upper portion of the active-site tunnel, where cis double bonds of the product reside, may be critical for determining the final product chain length. | 15447632 |
| 2007-11-05 21:39:00 | N-terminus verified by Edman degradation on complete protein | 9882662 |
| Type | IDs |
|---|---|
| Synonymous | ECK0173, rth, uppS, yaeS |
| Gene |
UniProtKB-ID:
UPPS_ECOLI
UniprotKB:
P60472
UniParc:
UPI0000137D08
EMBL:
U00096,
U70214,
AP009048
EnsemblGenome:
BAA77849,
b0174
KO:
eco:b0174,
ecj:JW0169
|
| Nucleutide sequences |
EMBL-CDS:
BAA77849.2,
AAC73285.1,
AAB08603.1
EnsemblGenome_TRS:
AAC73285,
BAA77849
|
| Protein sequencees |
EnsemblGenome_PRO:
BAA77849,
AAC73285
RefSeq:
NP_414716.1
|
| Others |
UniRef100:
UniRef100_P60474
UniRef90:
UniRef90_P60474
UniRef50:
UniRef50_Q6D8D8
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29986944 |
J. Bacteriol. William J MacCain , Suresh Kannan , Dannah Z Jameel , Jerry M Troutman , Kevin D Young |
2018-09-15 | - |
| 20828539 |
Mechanism of cis-prenyltransferase reaction probed by substrate analogues. Biochem. Biophys. Res. Commun. Yen-Pin Lu , Hon-Ge Liu , Kuo-Hsun Teng , Po-Huang Liang |
2010-10-01 |
ispU
|
| 19110475 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Hélène Barreteau , Sophie Magnet , Meriem El Ghachi , Thierry Touzé , Michel Arthur , Dominique Mengin-Lecreulx , Didier Blanot |
2009-01-15 |
ispU
|
| 18295483 |
Bioorg. Med. Chem. Lett. Stefan Peukert , Yingchuan Sun , Rui Zhang , Brian Hurley , Mike Sabio , Xiaoyu Shen , Christen Gray , JoAnn Dzink-Fox , Jianshi Tao , Regina Cebula , Sompong Wattanasin |
2008-03-15 |
ispU
|
| 17535895 |
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc. Natl. Acad. Sci. U.S.A. Rey-Ting Guo , Rong Cao , Po-Huang Liang , Tzu-Ping Ko , Tao-Hsin Chang , Michael P Hudock , Wen-Yih Jeng , Cammy K-M Chen , Yonghui Zhang , Yongcheng Song , Chih-Jung Kuo , Fenglin Yin , Eric Oldfield , Andrew H-J Wang |
2007-06-12 |
ispU
|
| 16515535 |
Biochem. J. Ferenc Marincs , Iain W Manfield , Jonathan A Stead , Kenneth J McDowall , Peter G Stockley |
2006-06-01 |
ispU,
metJ,
folE
|
| 16738553 |
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. Koji Hayashi , Naoki Morooka , Yoshihiro Yamamoto , Katsutoshi Fujita , Katsumi Isono , Sunju Choi , Eiichi Ohtsubo , Tomoya Baba , Barry L Wanner , Hirotada Mori , Takashi Horiuchi |
2006-01-01 |
pmrR,
torI,
yaeP,
ykfH,
ykgO,
ylcG,
rzoD,
ybdZ,
cydX,
gnsA,
insA,
ymgF,
ymiA,
yciX,
rzoR,
ynfO,
yniD,
yobH,
yoeB,
yohO,
arnE,
ypeB,
ypfN,
ypjJ,
arfA,
yheV,
ysaB,
sgcB,
yjhX,
ytjA,
yibT,
yicS,
yidD,
yifL,
ghoT,
yjjZ,
mntS,
iroK,
wecF,
yigE,
blr,
yggP,
cpxP,
hdfR,
thiS,
greB,
rtcA,
smf,
ygcU,
ypjK,
hokE,
sslE,
glcF,
glcE,
yhaM,
tdcG,
ytfR,
hokB,
ldrD,
hokA,
ldrA,
ldrB,
ecnA,
ecnB,
yfjD,
yhdP,
yjjV,
cysW,
hokC,
ghxQ,
tatD,
yjdP,
cutC,
nirC,
frlC,
aroK,
gntU,
dgoD,
dgoA,
dgoR,
yigL,
ldrC,
ylbE,
ydbJ,
yeiW,
yehK,
yneM,
ykfM,
ylcI,
yciY,
yncL,
ylcH,
ynhF,
yciZ,
ydgU,
ypfM,
ymgI,
ymgJ,
dinQ
|
| 16397293 |
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. Monica Riley , Takashi Abe , Martha B Arnaud , Mary K B Berlyn , Frederick R Blattner , Roy R Chaudhuri , Jeremy D Glasner , Takashi Horiuchi , Ingrid M Keseler , Takehide Kosuge , Hirotada Mori , Nicole T Perna , Guy Plunkett , Kenneth E Rudd , Margrethe H Serres , Gavin H Thomas , Nicholas R Thomson , David Wishart , Barry L Wanner |
2006-01-01 |
pmrR,
yfaS,
torI,
yaeP,
ykfH,
ykgO,
ylcG,
rzoD,
ybdZ,
cydX,
gnsA,
insA,
ymgF,
ymiA,
yciX,
rzoR,
ynfO,
yniD,
yobH,
yoeF,
yoeB,
yohO,
arnE,
ypdJ,
ypeB,
ypfN,
ypjJ,
arfA,
yheV,
ysaB,
sgcB,
yjhX,
ytjA,
yibT,
yicS,
yidD,
yifL,
ghoT,
yjjZ,
mntS,
iroK,
yifN,
wecF,
yigE,
blr,
yggP,
cpxP,
ygaY,
hdfR,
thiS,
yedN,
greB,
rtcA,
smf,
ygcU,
ypjK,
hokE,
sslE,
glcF,
glcE,
glvC,
yhaM,
tdcG,
ytfR,
yehH,
hokB,
ldrD,
hokA,
ldrA,
ldrB,
ecnA,
ecnB,
gapC,
yfjD,
yhdP,
yjjV,
cysW,
hokC,
ghxQ,
tatD,
yjdP,
cutC,
nirC,
frlC,
aroK,
gntU,
yedS,
dgoD,
dgoA,
dgoR,
yigL,
ldrC,
ylbE,
ydbJ,
yeiW,
yehK,
yaiX,
yoeA,
yneM
|
| 16738554 |
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. Tomoya Baba , Takeshi Ara , Miki Hasegawa , Yuki Takai , Yoshiko Okumura , Miki Baba , Kirill A Datsenko , Masaru Tomita , Barry L Wanner , Hirotada Mori |
2006-01-01 |
yafF,
ileS,
dapB,
ispH,
ftsA,
ftsZ,
folA,
murE,
ftsI,
lspA,
ftsL,
acpP,
murF,
mraY,
lpxC,
murD,
secA,
ftsQ,
secM,
can,
lpxB,
lpxA,
erpA,
dapD,
tsf,
bamA,
rseP,
ispU,
cdsA,
dnaE,
lpxD,
fabZ,
tilS,
accA,
yafN,
yagG,
pyrH,
lptD,
hemB,
dxr,
eno,
ispF,
dxs,
ispA,
adk,
ftsK,
dnaX,
rplT,
rpmA,
entD,
folD,
mrdB,
mrdA,
nadD,
fldA,
glnS,
lptG,
cydA,
pheT,
metK,
folC,
murJ,
infA,
cydC,
serS,
lpxK,
msbA,
rpsA,
kdsB,
mukF,
mukB,
mukE,
asnS,
fabA,
rplY,
ribD,
yceQ,
rne,
fabG,
holB,
tmk,
lolE,
lolD,
lolC,
purB,
cohE,
minE,
minD,
ribA,
pth,
fabD,
prs,
ispE,
lolB,
hemA,
prmC,
kdsA,
pgsA,
mqsA
|
| 15788389 |
J Biol Chem Rey-Ting Guo , Tzu-Ping Ko , Annie P-C Chen , Chih-Jung Kuo , Andrew H-J Wang , Po-Huang Liang |
2005-05-27 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
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