lpxA - UDP-N-acetylglucosamine acyltransferase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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944849 lpxA

基因描述

Type	Description
Definition	UDP-N-acetylglucosamine acyltransferase

研究结论

Date	Results	Publications
2014-10-11 10:10:00	Overlay of the LpxA-RJPXD33 structure with E. coli LpxD identified a complementary peptide binding pocket within LpxD and serves as a model for further biochemical characterization of RJPXD33 binding to LpxD.	24742680
2010-01-21 00:00:00	Results suggest that nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis.	17434525
2010-01-21 00:00:00	compact beta-turn structure of peptide 920 bound to LpxA may open previously uncharacterized approaches to the rational design of LpxA inhibitors with antibiotic activity	16835299
2010-01-21 00:00:00	show how LpxA selects for 14-carbon R-3-hydroxyacyl chains and reveal two modes of UDP binding	17698807
2007-11-05 21:38:00	N-terminus verified by Edman degradation on complete protein	8366124

名称对应

Type	IDs
Synonymous	ECK0180
Gene	UniProtKB-ID: LPXA_ECOLI UniprotKB: P0A722 UniParc: UPI0000112535 EMBL: U70214, U00096, M19334, AP009048 EnsemblGenome: b0181, BAA77856 KO: eco:b0181, ecj:JW0176
Nucleutide sequences	EMBL-CDS: AAC36918.1, AAB08610.1, AAC73292.1, BAA77856.2 EnsemblGenome_TRS: AAC73292, BAA77856
Protein sequencees	EnsemblGenome_PRO: AAC73292, BAA77856 RefSeq: NP_414723.1
Others	UniRef100: UniRef100_A7ZHS1 UniRef90: UniRef90_Q8X8X8 UniRef50: UniRef50_B4F258

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
24742680	Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis. J Biol Chem Ronald J Jenkins , Kyle A Heslip , Jennifer L Meagher , Jeanne A Stuckey , Garry D Dotson	2014-05-30	-
19604481	Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein. Structure Jay H Choi , Barnaby C H May , Cedric Govaerts , Fred E Cohen	2009-07-15	-
18304323	Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics Yasushi Ishihama , Thorsten Schmidt , Juri Rappsilber , Matthias Mann , F Ulrich Hartl , Michael J Kerner , Dmitrij Frishman	2008-01-01	-
17698807	Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proc. Natl. Acad. Sci. U.S.A. Allison H Williams , Christian R H Raetz	2007-08-21	-
17434525	Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis. J. Mol. Biol. Venkatasubramanian Ulaganathan , Lori Buetow , William N Hunter	2007-06-01	lpxA
17362200	Lipid A modification systems in gram-negative bacteria. Annu. Rev. Biochem. Christian R H Raetz , C Michael Reynolds , M Stephen Trent , Russell E Bishop	2007-01-01	lpxC, lpxB, lpxA, lpxD, lpxM, arnC, lpxK, msbA, lpxL, pagP, lpxP, arnT, arnB, arnA, waaF, waaC, waaR, waaO, waaB, waaY, waaU, waaG, waaP, waaQ, eptC, eptA, waaA, lpxH
17187058	Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat. Biotechnol. Peng Lu , Christine Vogel , Rong Wang , Xin Yao , Edward M Marcotte	2007-01-01	sspA, talB, dnaK, dnaJ, rpsT, ileS, dapB, carB, ftsZ, murE, aceF, acpP, surA, secA, can, aceE, panB, argF, lpxA, dksA, lpd, erpA, skp, dapD, acnB, tsf, glnH, fabZ, metQ, accA, galM, sodB, panC, pyrH, codA, opgG, pepD, tauB, eno, proC, phoR, thiI, gpmA, leuC, tig, clpP, clpX, lon, adk, htpG, acrB, trpD, apt, ydgH, rplT, purK, ompT, thrC, ybeD, ahpC, purR, glf, serA, miaB, pgm, seqA, rfbB, iscR, asnB, mprA, fldA, fur, sucA, sucB, hisJ, glnS, sucC, sucD, gltA, bioB, pheT, bioD, metK, sdhA, ybiC, tolB, ybiT, ldtB, moeA, gsiB, yliE, ihfA, serS, pflB, serC, aroA, ihfB, rpsA, mukE
16835299	Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proc. Natl. Acad. Sci. U.S.A. Allison H Williams , Robert M Immormino , Daniel T Gewirth , Christian R H Raetz	2006-07-18	-
16336047	Conserved and variable functions of the sigmaE stress response in related genomes. PLoS Biol. Virgil A Rhodius , Won Chul Suh , Gen Nonaka , Joyce West , Carol A Gross	2006-01-01	lpxB, lpxA, rnhB, skp, bamA, dnaE, lpxD, fabZ, opgG, yaiW, rutR, clpX, lon, ybfG, ompA, opgH, narW, rnt, lpp, ftnB, wza, wzb, wzc, hcp, yfeK, sbmA, yfeS, yfeX, yfeY, yfgD, bamB, der, bepA, rpoE, rseC, rseA, rseB, bamD, rnlB, dsbC, recJ, prfB, ahpF, bacA, cca, ygiM, ydhI, yraP, hcr, diaA, greA, rpoN, hpf, ptsN, lptB, yhbJ, gspA, fkpA, malQ, yhjJ, yicJ, yieE, plsB
16738554	Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. Tomoya Baba , Takeshi Ara , Miki Hasegawa , Yuki Takai , Yoshiko Okumura , Miki Baba , Kirill A Datsenko , Masaru Tomita , Barry L Wanner , Hirotada Mori	2006-01-01	yafF, ileS, dapB, ispH, ftsA, ftsZ, folA, murE, ftsI, lspA, ftsL, acpP, murF, mraY, lpxC, murD, secA, ftsQ, secM, can, lpxB, lpxA, erpA, dapD, tsf, bamA, rseP, ispU, cdsA, dnaE, lpxD, fabZ, tilS, accA, yafN, yagG, pyrH, lptD, hemB, dxr, eno, ispF, dxs, ispA, adk, ftsK, dnaX, rplT, rpmA, entD, folD, mrdB, mrdA, nadD, fldA, glnS, lptG, cydA, pheT, metK, folC, murJ, infA, cydC, serS, lpxK, msbA, rpsA, kdsB, mukF, mukB, mukE, asnS, fabA, rplY, ribD, yceQ, rne, fabG, holB, tmk, lolE, lolD, lolC, purB, cohE, minE, minD, ribA, pth, fabD, prs, ispE, lolB, hemA, prmC, kdsA, pgsA, mqsA

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