| Type | Description |
|---|---|
| Definition | Jrk helix-turn-helix protein |
| Date | Results | Publications |
|---|---|---|
| 2017-09-02 10:24:00 | JRK expression was aberrantly elevated in 21% of colorectal cancers, 15% of breast and ovarian cancers and was associated with increased expression of beta-catenin target genes and increased cell proliferation | 26455321 |
| 2017-08-05 11:49:00 | in the adult intestine, Ebd acts independently of Ewg in physiological Wnt signaling, but cooperates with Ewg to induce the hyperactivation of Wnt target gene expression following Apc1 loss. These findings have relevance for human tumorigenesis, as Jerky (JRK/JH8), the human Ebd homolog, promotes Wnt pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers | 28708826 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | JH8, jerky |
| Gene |
UniProtKB-ID:
JERKY_HUMAN
UniprotKB:
O75564
UniParc:
UPI0000EE7A80,
UPI000000DA37
EMBL:
KC877375,
BC043351,
CH471162,
AF072467,
AC108002,
AF072468
Ensembl:
ENSG00000234616
KO:
hsa:8629
|
| Nucleutide sequences |
EMBL-CDS:
EAW82317.1,
AAC32352.1,
AAH43351.1,
AAC32353.1,
EAW82315.1,
EAW82316.1
Ensembl_TRS:
ENST00000571961,
ENST00000614134,
ENST00000612905,
ENST00000615982
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000461610,
ENSP00000482410,
ENSP00000483808,
ENSP00000485390
RefSeq:
XP_011515656.1,
XP_006716740.1,
NP_001070995.2,
NP_003715.3,
XP_011515657.1,
NP_001266281.1,
XP_006716741.1
|
| Others |
UniRef100:
UniRef100_O75564
UniRef90:
UniRef90_O75564
UniRef50:
UniRef50_O75564
UniGene:
Hs.535903,
Hs.683465
CCDS:
CCDS75796.1,
CCDS75797.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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