| Type | Description |
|---|---|
| Definition | U4/U6-U5 snRNP complex subunit PRP8 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 14:08:00 | Results suggest that the Snu114-GTP-Prp8 module serves as a relay station during spliceosome activation and disassembly, but that GTPase activity may be dispensable for splicing. | 32196113 |
| 2019-12-14 12:04:00 | Deletion of the ZF domain or mutation of the conserved ZF residues greatly weakened the association of Cwc24 with the spliceosome, and lowered the affinity and specificity of its interaction with the 5' splice site, resulting in atypical interactions of U5, U6 and Prp8 with the 5' splice site, and aberrant cleavage at the 5' splice site | 31504764 |
| 2018-04-28 10:16:00 | error-prone/efficient RH alleles suppress a prp2 mutant deficient at promoting the first catalytic step of splicing, whereas hyperaccurate/inefficient RH alleles exhibit synthetic sickness. Together our data indicate that prp8 RH alleles link splicing fidelity with catalytic efficiency by biasing the relative stabilities of distinct spliceosome conformations. | 28416677 |
| 2016-04-30 11:14:00 | Upon step 1 catalysis, Cwc25 contacts with the branch-site region, and enhanced crosslinks of Prp8 and Prp45 with nucleotides surrounding the branch-site were observed. | 26393790 |
| 2014-05-10 10:12:00 | We propose that the U5 snRNA IL1 is a platform for protein binding and is required for , Brr2 and Snu114 association with the U5 snRNA to form the U5 snRNP. | 23857713 |
| Type | IDs |
|---|---|
| Synonymous | DBF3, DNA39, RNA8, SLT21, USA2 |
| Gene |
UniProtKB-ID:
PRP8_YEAST
UniprotKB:
P33334
UniParc:
UPI000013213D
EMBL:
Z24732,
U00027,
BK006934,
L29421
EnsemblGenome:
YHR165C
KO:
sce:YHR165C
|
| Nucleutide sequences |
EMBL-CDS:
DAA06858.1,
CAA80854.1,
AAA67044.1,
AAB68011.1
EnsemblGenome_TRS:
YHR165C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YHR165C
RefSeq:
NP_012035.1
|
| Others |
UniRef100:
UniRef100_P33334
UniRef90:
UniRef90_P33334
UniRef50:
UniRef50_P33334
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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