Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.
Proc. Natl. Acad. Sci. U.S.A.2017 May 02;114(18):4739-4744. Epub 2017 Apr 17
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摘要
RH alleles link splicing fidelity with catalytic efficiency by biasing the relative stabilities of distinct spliceosome conformations. We hypothesize that the spliceosome "toggles" between such error-prone/efficient and hyperaccurate/inefficient conformations during the splicing cycle to regulate splicing fidelity.
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基因功能
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原始数据
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文献解读
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