LYS1 - saccharopine dehydrogenase (NAD+, L-lysine-forming)-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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854852 LYS1

基因描述

Type	Description
Definition	saccharopine dehydrogenase (NAD+, L-lysine-forming)

研究结论

Date	Results	Publications
2012-03-24 11:13:00	investigation of crystal structure and catalytic mechanism of LYS1: Data are consistent with role for K77 acting as base accepting proton from lysine prior to nucleophilic attack and with role for H96 acting as acid-base catalyst to form imine.	22243403
2011-10-15 11:29:00	A disulfide bond between cys-205 and cys-249, in the vicinity of the NAD-binding site, is observed in the apoenzyme, while a dithiol is observed in a structure with AMP bound, suggesting preferential binding of the dinucleotide to reduced enzyme.	21798231
2010-01-21 00:00:00	In the direction of lysine formation, once NAD+ and saccharopine bind, a group with a pKa of 6.2 accepts a proton from the secondary amine of saccharopine as it is oxidized.	17223709

名称对应

Type	IDs
Gene	UniProtKB-ID: LYS1_YEAST UniprotKB: P38998 UniParc: UPI0000168354 EMBL: Z38061, BK006942, X77362 EnsemblGenome: YIR034C KO: sce:YIR034C
Nucleutide sequences	EMBL-CDS: DAA08581.1, CAA54551.1, CAA86194.1 EnsemblGenome_TRS: YIR034C_mRNA
Protein sequencees	EnsemblGenome_PRO: YIR034C RefSeq: NP_012300.3
Others	UniRef100: UniRef100_P38998 UniRef90: UniRef90_P38998 UniRef50: UniRef50_P38998

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
29158339	Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) Jason E Miller , Liye Zhang , Haoyang Jiang , Yunfei Li , B Franklin Pugh , Joseph C Reese	2018-01-04	-
28928432	Two NAD-linked redox shuttles maintain the peroxisomal redox balance in Saccharomyces cerevisiae. Sci Rep Nadal A Al-Saryi , Murtakab Y Al-Hejjaj , Carlo W T van Roermund , Georgia E Hulmes , Lakhan Ekal , Chantell Payton , Ronald J A Wanders , Ewald H Hettema	2017-09-19	-
28109174	Î±Î²'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. FEBS J. JosÃ© Carlos Ponce-Rojas , Maria Clara AvendaÃ±o-Monsalve , Armando Roberto YaÃ±ez-FalcÃ³n , Fabiola Jaimes-Miranda , Erika Garay , Francisco Torres-Quiroz , Alexander DeLuna , Soledad Funes	2017-03-01	-
27821408	A novel translational control mechanism involving RNA structures within coding sequences. Genome Res. Jennifer Jungfleisch , Danny D Nedialkova , Ivan Dotu , Katherine E Sloan , Neus Martinez-Bosch , Lukas BrÃ¼ning , Emanuele Raineri , Pilar Navarro , Markus T Bohnsack , Sebastian A Leidel , Juana DÃez	2017-01-01	-
26668354	Target selection by natural and redesigned PUF proteins. Proc. Natl. Acad. Sci. U.S.A. Douglas F Porter , Yvonne Y Koh , Brett VanVeller , Ronald T Raines , Marvin Wickens	2016-12-29	-
25026036	A dynamic interface between vacuoles and mitochondria in yeast. Dev. Cell Yael Elbaz-Alon , Eden Rosenfeld-Gur , Vera Shinder , Anthony H Futerman , Tamar Geiger , Maya Schuldiner	2014-07-14	YIL002W-A, MRC1, KRR1, SRO9, RRP7, RNQ1, GBP2, CDC10, MRPL32, CIT2, RVS161, SLM5, RHB1, SYP1, YCR043C, IMG1, THR4, PWP2, PAT1, SRB8, RGD2, SEC53, LAM5, TUB2, RPO41, MOB2, GYP8, BUD27, FRS2, MDJ1, SMC1, SPB4, LOC1, GSY1, FAB1, SMC2, RPL2A, RPL29, ERJ5, RMD8, RET2, RPN12, VPS13, RIX7, YLL032C, DPS1, PUF3, SOF1, PSR1, DRS1, LMO1, MMM1, RPL8B, NOC3, RLP24, PSR2, RPL15A, FCF2, SPT8, FRS1, RPL22A, RGR1, RPL10, CSF1, XDJ1, GEP5, MDN1, CFT2, MSL5, DIP2, ACE2, DPH6, PEP3, ACS2, SEC10, CBF5, NOP56, TUB4, MSC3, RSA3, UTP13, LCB5, DCS1, SMD2, DBP9, YLR281C, GCD7, STT4, IMH1, CDC25, MRPL15, BUD6, RPP0, BUD8, ADE13, STE11, ROM2, IKI3, VAC14
23332755	The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell Felix Willmund , Marta del Alamo , Sebastian Pechmann , Taotao Chen , VÃ©ronique AlbanÃ¨se , Eric B Dammer , Junmin Peng , Judith Frydman	2013-01-17	VAC17, MIC10, PRD1, KAR4, PBN1, APA1, POF1, MGR1, GLK1, SRO9, GFD2, GRX1, LSB5, RNQ1, HBN1, DCC1, GBP2, ILV6, STP22, CDC10, YCP4, CIT2, RVS161, PGK1, RHB1, RIM1, SYP1, RPS14A, RRP43, YCR043C, YCR051W, THR4, CTR86, PWP2, YIH1, TAH1, HCM1, RSA4, SOL2, FUB1, PAT1, AHC2, TRX3, TUP1, CSM1, YCR090C, MSH3, YCR102C, SNZ3, SWP82, RGD2, SEC53, OTU1, ACT1, YPT1, TUB2, MOB2, RPL22B, HAC1, CAF16, FRS2, GAT1, LPD1, BLM10, SEC4, VTC2, SPB4, RPN11, YFR006W, YFH7, IOC3, ATG18, LSB3, HIS2, CDC14, RPL2A, DUG1, BNA6, RMD8, YMR31, PRE4, RET2, RPN12, HXK1, IRC7, GRC3, RIX7, YLL032C, FRA1, ISA1, HSP104, SSA2, HIF1, DPS1, LMO1, ORC3, RTT109, MHT1, YLL058W
23050238	Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda) Alison C Douglas , Andrew M Smith , Sara Sharifpoor , Zhun Yan , Tanja Durbic , Lawrence E Heisler , Anna Y Lee , Owen Ryan , Hendrikje GÃ¶ttert , Anu Surendra , Dewald van Dyk , Guri Giaever , Charles Boone , Corey Nislow , Brenda J Andrews	2012-10-01	YDR182W-A, NFS1, BUD3, PMP1, ABP1, ALR2, MMM1, PML1, POM34, MEF1, GIS3, YLR126C, NOP56, MSS51, IFH1, ECM22, NDL1, CWC24, RPS29A, MFG1, DUN1, PMT1, MTF2, RTK1, PSF1, RPS11A, RPC11, MAK21, TPS2, YDR090C, UBC1, CBS2, SNU56, MET32, RMD5, MTH1, HDA2, PEP7, PEX3, MSN5, LCD1, PLM2, SDH7, FDC1, PRE7, MRPL16, MCM2, ALK2, RCR1, PDX3, RDH54, RAD16, YSY6, PBP2, SAE2, XRN1, RCK1, GPI10, NUP145, MRH4, DUO1, SDS23, ERG4, STF2, YGR012W, SNU71, SMD1, RRP46, PBP1, AMA1, PEX21, PUP2, HUA1, EFG1, BIO2, ASG7, QCR8, PBS2, SIP4, APS3, RAD26, HUL4, MGM101, MCR1, CMC1, HAP4, ALY1, DID2, BET3, PPM2, SPO21, PSH1, RTS1, MSA1, LSC1, RPB2, PET123, MSB1, PUS7
22243403	Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry Vidya Prasanna Kumar , Leonard M Thomas , Kostyantyn D Bobyk , Babak Andi , Paul F Cook , Ann H West	2012-01-31	LYS1
22953000	Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1. PLoS ONE Eric J Milliman , Neelu Yadav , Yin-Chu Chen , Bhavana Muddukrishna , Sheelarani Karunanithi , Michael C Yu	2012-01-01	STE50, LDB16, SLM5, SNF7, ERG3, YKE2, RSC2, ELO3, TPD3, DEP1, VMA1, RXT3, RPL31A, SIT4, TRP1, EMC10, DOA4, TFB5, NGG1, UME6, MRPL35, MSN5, DYN2, ADA2, KRE28, RIB1, LDB7, EDS1, HMT1, UBP14, RPL19A, RXT2, GRS1, CCZ1, UMP1, BEM1, SWC5, APM3, YRB30, YIP5, YGL159W, ARI1, PEX14, NUT1, ARO2, RPL9A, SOH1, SGF73, RAD6, RIM8, OCH1, VMA7, CAF130, PRE9, ADE3, GCN5, MAL12, PFD1, SWI3, MEF2, JEM1, YJR011C, GRR1, VPH2, VMA5, MRPL13, YGK3, MSN1, SIN3, PHO80, HST3, EXO1, PEP12, WHI5, MGM1, RIM20, SNF2, SDS3, SEC28, FIS1, LYS1, PML39, ARG81, GIM5, HMG1, FPR3, NGL3, TVP18, VPS20, CTF18, SNZ1, RIM13, SAP30, RPD3, MRPL10, BNI1, ALP1, GIM3, PHO23

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