| Type | Description |
|---|---|
| Definition | Hsp70 family ATPase KAR2 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-30 12:33:00 | Reductive stress in the endoplasmic reticulum (ER) inhibits the Ost3-dependent N-glycosylation of Sil1, which regulates specific BiP functions appropriate to the needs of the ER under reductive stress. | 29109265 |
| 2017-12-16 10:45:00 | Here the authors demonstrate that BiP's nucleotide exchange factor - Sil1 - can reverse BiP cysteine oxidation. | 28257000 |
| 2017-10-14 13:10:00 | Increased endoplasmic reticulum glutathione import triggers H2O2-dependent Bip oxidation through Ero1 reductive activation, which inhibits glutathione import in a negative regulatory loop. | 28918898 |
| 2017-06-24 12:25:00 | The authors found that the ATPase activity displayed by unmodified Kar2 is fully maintained when Cys63 is replaced with Ala or Val. | 27543005 |
| 2016-08-20 10:18:00 | the susceptibility of BiP to modification with glutathione may serve also to prevent irreversible oxidation of BiP by peroxide. | 26865632 |
| Type | IDs |
|---|---|
| Synonymous | GRP78 |
| Gene |
UniProtKB-ID:
BIP_YEAST
UniprotKB:
P16474
UniParc:
UPI0000036C61
EMBL:
M25064,
Z49309,
BK006943,
M25394,
M31006
EnsemblGenome:
YJL034W
KO:
sce:YJL034W
|
| Nucleutide sequences |
EMBL-CDS:
DAA08765.1,
AAA34714.1,
AAA34713.1,
AAA34454.1,
CAA89325.1
Gene_ORFName:
J1248
EnsemblGenome_TRS:
YJL034W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YJL034W
RefSeq:
NP_012500.3
|
| Others |
UniRef100:
UniRef100_P16474
UniRef90:
UniRef90_P16474
UniRef50:
UniRef50_P16474
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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