| Type | Description |
|---|---|
| Definition | Lcd1p |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:08:00 | the C-terminal of Ddc1 has structural flexibility and it plays a critical role for Mec1/Ddc2 activation in G1/G2 phase; the 9-1-1 complex and Rad24-RFC interact | 31182279 |
| 2020-06-13 11:38:00 | This study presents functional and structural characterization of the physical interaction between Dpb11 and Mec1-Ddc2 complex. | 31349966 |
| 2020-01-11 11:32:00 | Study shows that Ddc2 promotes Mec1 activation independently of Ddc1/Dpb11/Dna2 function in vivo and through ssDNA recognition in vitro. The ddc2-S4 mutation diminishes damage-induced phosphorylation of the checkpoint mediators, Rad9 and Mrc1. Rad9 controls checkpoint throughout the cell-cycle whereas Mrc1 is specifically required for the S-phase checkpoint. | 31369547 |
| 2019-03-30 10:12:00 | Rad52-RFP and Rad51-GFP co-localize to the same DSB, but a significant minority of foci have Rad51-GFP without visible Rad52-RFP. We conclude that co-localization of foci in cells with 3 DSBs does not represent formation of a homologous recombination "repair center," as the same distribution of Ddc2-GFP foci was found in the absence of the Rad52 protein. | 30822309 |
| 2018-03-17 10:47:00 | this study determined the structure of intact Mec1-Ddc2 (the yeast homolog of ATR-ATRIP), which is poised for catalysis, at a resolution of 3.9 angstroms. | 29191911 |
| Type | IDs |
|---|---|
| Synonymous | DDC2, PIE1 |
| Gene |
UniProtKB-ID:
LCD1_YEAST
UniprotKB:
Q04377
UniParc:
UPI0000036C3D
EMBL:
U33057,
BK006938
EnsemblGenome:
YDR499W
KO:
sce:YDR499W
|
| Nucleutide sequences |
EMBL-CDS:
AAB64941.1,
DAA12331.1
EnsemblGenome_TRS:
YDR499W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YDR499W
RefSeq:
NP_010787.3
|
| Others |
UniRef100:
UniRef100_Q04377
UniRef90:
UniRef90_Q04377
UniRef50:
UniRef50_Q04377
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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