Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes.

J Cell Biol. 2020 May 04;219(5)

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摘要

A single particle cryo-EM reconstruction of an â¼160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an â¼160-Ã long channel lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties. The structure suggests that VPS13 and related proteins, like the autophagy protein ATG2, can act as bridges between organelle membranes to allow bulk lipid flow between organelles.

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Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes.

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