| Type | Description |
|---|---|
| Definition | LSM10, U7 small nuclear RNA associated |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 12:05:00 | While the molecular basis for this altered cleavage activity is unknown, one possibility is that binding of Lsm10 and Lsm11 to the spliceosomal Sm site affects the overall geometry of the U7-specific Sm ring, resulting in misalignment of the CPSF73 endonuclease with the substrate. | 31819999 |
| 2017-09-16 10:37:00 | FLASH plays two roles in 3' end processing of histone pre-mRNAs: It interacts with Lsm11 to form a docking platform for the polyadenylation factors, and it cooperates with SLBP to recruit U7 snRNP to histone pre-mRNA. | 28289156 |
| 2010-01-21 00:00:00 | The subnuclear organization of histone gene regulatory proteins and 3' end processing factors (NPAT/LSM10) of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. | 19277982 |
| 2010-01-21 00:00:00 | The overexpression of Lsm10 and Lsm11 increases the cellular levels of U7 snRNP but has no effect on histone pre-mRNA processing. | 16914750 |
| 2010-01-21 00:00:00 | Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 and SMN complexes | 16087681 |
| Type | IDs |
|---|---|
| Synonymous | MST074, MSTP074 |
| Gene |
UniProtKB-ID:
LSM10_HUMAN
UniprotKB:
Q969L4
UniParc:
UPI000012E96D
EMBL:
AF394685,
BC007623
Ensembl:
ENSG00000181817
KO:
hsa:84967
|
| Nucleutide sequences |
EMBL-CDS:
AAH07623.1,
AAL07689.1
Ensembl_TRS:
ENST00000315732
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000319341
RefSeq:
NP_116270.1
|
| Others |
UniRef100:
UniRef100_Q969L4
UniRef90:
UniRef90_Q969L4
UniRef50:
UniRef50_Q969L4
UniGene:
Hs.603131
CCDS:
CCDS408.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31819999 |
Composition and processing activity of a semi-recombinant holo U7 snRNP. Nucleic Acids Res. Katarzyna Bucholc , Wei Shen Aik , Xiao-Cui Yang , Kaituo Wang , Z Hong Zhou , MichaÅ Dadlez , William F Marzluff , Liang Tong , Zbigniew Dominski |
2020-02-20 | - |
| 28977470 |
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer. Nucleic Acids Res. Madhumitha Rengasamy , Fan Zhang , Ajay Vashisht , Won-Min Song , Francesca Aguilo , Yifei Sun , SiDe Li , Weijia Zhang , Bin Zhang , James A Wohlschlegel , Martin J Walsh |
2017-11-02 | - |
| 28289156 |
RNA Aleksandra Skrajna , Xiao-Cui Yang , Katarzyna Bucholc , Jun Zhang , Traci M Tanaka Hall , MichaÅ Dadlez , William F Marzluff , Zbigniew Dominski |
2017-06-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 28431233 |
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol. Cell Thomas Treiber , Nora Treiber , Uwe Plessmann , Simone Harlander , Julia-Lisa Daià , Norbert Eichner , Gerhard Lehmann , Kevin Schall , Henning Urlaub , Gunter Meister |
2017-04-20 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 22658674 |
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell Alfredo Castello , Bernd Fischer , Katrin Eichelbaum , Rastislav Horos , Benedikt M Beckmann , Claudia Strein , Norman E Davey , David T Humphreys , Thomas Preiss , Lars M Steinmetz , Jeroen Krijgsveld , Matthias W Hentze |
2012-06-08 |
GNPDA1,
SCARNA27,
GABPB1-AS1,
NFYC-AS1,
FKSG29,
PHKA2-AS1,
HDAC6,
PDCD6,
C17orf96,
LOC100287042,
MIR3652,
ARPC4-TTLL3,
ATP5J2-PTCD1,
TGIF2-C20orf24,
FARSB,
ABCC5,
ABCF2,
HUWE1,
ARPC4,
ARPC1B,
ACTR3,
ACTR1A,
LRPPRC,
TRAP1,
BCAP31,
NAMPT,
RBM12,
TOB1,
G3BP1,
SUGP2,
MBNL2,
ABI2,
CEBPZ,
ATP6AP2,
SLC25A15,
RCL1,
RBM7,
RBM6,
RBM5,
ALYREF,
PSME3,
MPHOSPH10,
NUTF2,
USPL1,
DDX39A,
STX6,
HNRNPR,
MRPS31,
RIDA,
SF3B4,
AKAP8,
STUB1,
SIGMAR1,
SMNDC1,
BCAS2,
SF3A1,
CDKN2A,
APBB3,
SMYD5,
ADAR,
EMC8,
NPM3,
HMG20A,
NOD1,
RACK1,
NDC80,
NSA2,
YAP1,
CD2BP2,
TUBGCP3,
RBM14,
EMG1,
ACAA2,
PPIE,
TAB1,
MAD2L2,
PIBF1,
SLC25A17,
NXF1,
CREB3,
LRRC41,
SYNCRIP,
ENOX2,
MYBBP1A,
DDX17,
ADARB2,
CHERP,
HYOU1,
IPO8,
NOP56,
RNASEH2A,
GLRX3,
DCTN2,
LAMTOR5,
PRDX4,
AGPAT1,
RPP30,
SLU7,
MRPL28
|
| 19928837 |
The SMN interactome includes Myb-binding protein 1a. J. Proteome Res. Heidi R Fuller , Nguyen Thi Man , Le Thanh Lam , Le Thiet Thanh , Rebecca A Keough , Arndt Asperger , Thomas J Gonda , Glenn E Morris |
2010-01-01 |
HNRNPR,
MYBBP1A,
DDX17,
NOP56,
STRAP,
DDX20,
LSM11,
DDX5,
ERH,
FBL,
EWSR1,
HNRNPA1,
HNRNPA2B1,
HNRNPH1,
HNRNPH3,
NONO,
NPM1,
P4HA1,
GEMIN4,
NOP58,
GEMIN8,
ACTB,
RPL6,
RPL7,
RPL10,
RPL13,
SFPQ,
SRSF3,
SMN1,
SMN2,
SNRNP70,
SNRPA1,
SNRPB,
SNRPD1,
SNRPD2,
SNRPF,
SNRPG,
TMPO,
GEMIN7,
GEMIN6,
HIST2H2AC,
HIST1H4A,
GEMIN2,
LSM10,
FUBP1,
THRAP3
|
| 19277982 |
J Cell Physiol Prachi N Ghule , Zbigniew Dominski , Jane B Lian , Janet L Stein , Andre J van Wijnen , Gary S Stein |
2009-07-01 | - |
| 19060904 |
An empirical framework for binary interactome mapping. Nat. Methods Kavitha Venkatesan , Jean-François Rual , Alexei Vazquez , Ulrich Stelzl , Irma Lemmens , Tomoko Hirozane-Kishikawa , Tong Hao , Martina Zenkner , Xiaofeng Xin , Kwang-Il Goh , Muhammed A Yildirim , Nicolas Simonis , Kathrin Heinzmann , Fana Gebreab , Julie M Sahalie , Sebiha Cevik , Christophe Simon , Anne-Sophie de Smet , Elizabeth Dann , Alex Smolyar , Arunachalam Vinayagam , Haiyuan Yu , David Szeto , Heather Borick , Amélie Dricot , Niels Klitgord , Ryan R Murray , Chenwei Lin , Maciej Lalowski , Jan Timm , Kirstin Rau , Charles Boone , Pascal Braun , Michael E Cusick , Frederick P Roth , David E Hill , Jan Tavernier , Erich E Wanker , Albert-László Barabási , Marc Vidal |
2009-01-01 |
TROAP,
FSBP,
STAM2,
MCRS1,
MAD2L2,
SYNCRIP,
APPBP2,
RABAC1,
PAICS,
STAMBP,
C10orf10,
CDC42EP1,
FSTL1,
POLI,
SDSL,
LENG8,
CKB,
FAM46B,
EVI5L,
ARL11,
BATF2,
RAB3IP,
MIEF2,
COL8A1,
NEU4,
ALS2CR12,
ZFAND2B,
CCDC148,
COMT,
GLYCTK,
FAM92A1,
ASB9,
CRYBA2,
SLC25A10,
EXOC8,
CYBA,
C8orf48,
DHPS,
DUT,
EIF4E,
EML1,
KIF6,
BEND7,
FDPS,
FES,
RRAS2,
PHLDA1,
DKK1,
TRIM32,
NT5C2,
TCF25,
EPB41L3,
GSE1,
ARL6IP1,
SYT11,
MTUS2,
RBFOX2,
RASD2,
DDAH2,
CCNDBP1,
LDOC1,
GABPB1,
RAD54B,
APPL1,
NAT9,
PITPNC1,
FAM50B,
CNNM3,
CHIC2,
GEM,
TUBGCP4,
LSM3,
GP9,
MAGEB18,
C11orf54,
DBNL,
NXT1,
GSTM3,
SERTAD3,
HOXA9,
HOXB9,
HPRT1,
AQP1,
IL16,
AQP5,
JUP,
TRIM23,
LASP1,
LIMS1,
LRCH4,
ARRB2,
C10orf62,
MDFI,
MLH1,
MTF1,
NDUFA7,
NFYA,
NME1,
PARK2
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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