| Type | Description |
|---|---|
| Definition | histidine triad nucleotide binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 10:09:00 | Multivariate analyses revealed that tumor size and HINT2 expression are risk factors for Hepatocellular carcinoma recurrence. HINT2 is down-regulated in Hepatocellular carcinoma, and low HINT2 expression predicts earlier tumor recurrence. HINT2 expression may serve as a prognostic indicator of recurrence in Hepatocellular carcinoma. | 31770197 |
| 2019-03-16 12:54:00 | Decreased electron transfer and oxidative phosphorylation capacity in the absence of HINT-2. | 29913563 |
| 2017-12-09 10:26:00 | Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression. | 28947137 |
| 2017-09-23 11:06:00 | HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion. | 28088787 |
| 2014-02-01 12:20:00 | Low HINT2 expression is associated with low response to therapy in endometrial cancer. | 23682076 |
| Type | IDs |
|---|---|
| Synonymous | HIT-17 |
| Gene |
UniProtKB-ID:
HINT2_HUMAN
UniprotKB:
Q9BX68
UniParc:
UPI000000DC49
EMBL:
AF356515,
BC047737,
AF356875,
CH471071,
AY033094,
AF490476,
AL133410
Ensembl:
ENSG00000137133
KO:
hsa:84681
|
| Nucleutide sequences |
EMBL-CDS:
AAH47737.1,
AAM09526.1,
AAK53455.1,
AAM00221.1,
EAW58332.1,
AAK37562.1
Ensembl_TRS:
ENST00000259667
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000259667
RefSeq:
NP_115982.1,
XP_024303471.1,
XP_024303470.1,
XP_024303472.1
|
| Others |
UniRef100:
UniRef100_Q9BX68
UniRef90:
UniRef90_Q9BX68
UniRef50:
UniRef50_Q9BX68
UniGene:
Hs.70573
CCDS:
CCDS6594.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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