| Type | Description |
|---|---|
| Definition | melanoma cell adhesion molecule |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:12:00 | data indicate that CD146 deficiency is associated with the upregulation of RANTES production and increased inflammation of atheroma, which could influence the atherosclerotic plaque fate. Thus, these data identify CD146 agonists as potential new therapeutic candidates for atherosclerosis treatment. | 30928429 |
| 2019-12-14 11:29:00 | Study demonstrated that a cross-regulation between CD146 and HIF-1alpha in pulmonary artery smooth muscle cells triggers pulmonary vascular remodeling. CD146 promotes HIF-1alpha transcriptional program through NF-kappaB and HIF-1alpha upregulates CD146 through direct binding to its promoter region. These findings uncover previously uncharacterized hypoxic reprogramming during vascular remodeling. | 31391533 |
| 2019-08-10 12:16:00 | Study provide explicit evidence that CD146, with elevated expression and activity in a variety of cancers, is a key factor involved in the cadherin switch. CD146 overexpression significantly promotes epithelial-mesenchymal transition (EMT) in both mouse embryonic fibroblasts (MEFs) and ovarian cancer cells. Furthermore, CD146-deficient MEFs exhibited decreased motility as a result of reversion in this cadherin switch. | 29777784 |
| 2018-11-03 10:35:00 | findings suggest that MCAM is a gene upregulated and involved in maintaining PPARgamma induction in the late but not in the early stages of 3T3-L1 fibroblasts adipogenesis. | 29468504 |
| 2018-05-26 11:39:00 | The dynamic expression of CD146 controls the behavior of ECs and pericyte. | 28827364 |
| Type | IDs |
|---|---|
| Synonymous | 1-gicerin, AV025631, CD146, CD149, Muc18, s-endo, s-gicerin |
| Gene |
UniProtKB-ID:
MUC18_MOUSE
UniprotKB:
Q8R2Y2
UniParc:
UPI00000E7A68,
UPI00006688C3
EMBL:
AJ297451,
AB035508,
AJ297450,
AB035509,
BC026985
Ensembl:
ENSMUSG00000032135
KO:
mmu:84004
|
| Nucleutide sequences |
EMBL-CDS:
BAB16051.1,
CAB97362.1,
CAB97363.1,
AAH26985.1,
BAB16050.1
Ensembl_TRS:
ENSMUST00000034650,
ENSMUST00000098852
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000096451,
ENSMUSP00000034650
RefSeq:
XP_036011310.1,
NP_075548.2,
NP_001346459.1,
XP_030100603.1,
XP_030100602.1
|
| Others |
UniRef100:
UniRef100_Q8R2Y2
UniRef90:
UniRef90_Q9EPF2
UniRef50:
UniRef50_Q9EPF2
UniGene:
Mm.275003
CCDS:
CCDS90545.1,
CCDS23097.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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