CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.

Proc. Natl. Acad. Sci. U.S.A.2017 Sep 05;114(36):E7622-E7631. Epub 2017 Aug 21

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in pericytes, which have defects in pericyte coverage and BBB integrity, we demonstrate that CD146 functions as a coreceptor of PDGF receptor-Î² to mediate pericyte recruitment to cerebrovascular ECs. Moreover, we found that the attached pericytes in turn down-regulate endothelial CD146 by secreting TGF-Î²1 to promote further BBB maturation. These results reveal that the dynamic expression of CD146 controls the behavior of ECs and pericytes, thereby coordinating the formation of a mature and stable BBB.

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CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.

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