| Type | Description |
|---|---|
| Definition | phosphoinositide-3-kinase adaptor protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:39:00 | BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-kappaB and PI3K/AKT Signaling During Infection. | 32133012 |
| 2020-07-04 10:57:00 | B-cell phosphoinositide 3-kinase adapter protein 1 (BCAP) delayed the recruitment and activation of pro-caspase-1 within the NLRP3/ASC preinflammasome through its association with Flightless-1, suggesting BCAP is a multifunctional signaling adaptor that inhibits key pathogen-sensing pathways in macrophages. | 31088976 |
| 2020-01-04 12:09:00 | a novel role for BCAP in promoting TLR-induced IFN-alpha production in pDC and in systemic lupus erythematosus pathogenesis. | 30936294 |
| 2019-09-07 10:20:00 | induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8(+) T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development. | 30093532 |
| 2019-09-07 10:20:00 | BCAP is critical for IL-1R-induced phosphoinositide 3-kinase-Akt-mechanistic target of rapamycin (mTOR) activation, and minimal inhibition of mTOR completely abrogated IL-1beta-induced differentiation of pathogenic Th17 cells, mimicking BCAP deficiency. | 30093533 |
| Type | IDs |
|---|---|
| Synonymous | 1810044J04Rik, BCAP |
| Gene |
UniProtKB-ID:
BCAP_MOUSE
UniprotKB:
Q9EQ32
UniParc:
UPI00005AC973,
UPI000002736C,
UPI000175024A
EMBL:
AK170925,
AF293806,
AK150114,
AK153548,
BC113141,
AK089785,
AK170130,
AK087722,
AK171021
Ensembl:
ENSMUSG00000025017
KO:
mmu:83490
|
| Nucleutide sequences |
EMBL-CDS:
BAE42191.1,
BAE29318.1,
AAI13142.1,
BAE41584.1,
BAE32085.1,
BAE42118.1,
BAC40962.1,
AAG48584.1,
BAC39980.1
Ensembl_TRS:
ENSMUST00000059672
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000052777
RefSeq:
XP_006527535.1,
NP_113553.1
|
| Others |
UniRef100:
UniRef100_Q9EQ32
UniRef90:
UniRef90_Q9EQ32
UniRef50:
UniRef50_Q9EQ32
UniGene:
Mm.222266
CCDS:
CCDS37987.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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