B cell adaptor for PI3-kinase (BCAP) modulates CD8⁺ effector and memory T cell differentiation.

CD8⁺ T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8⁺ T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8⁺ T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8⁺ T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development.

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