| Type | Description |
|---|---|
| Definition | DiGeorge syndrome critical region gene 6 |
| Date | Results | Publications |
|---|---|---|
| 2016-12-17 10:11:00 | the frequency of a recurrent small 22q11.2 deletion encompassing PRODH and the neighboring DGCR6 gene in three case-control studies, was studied. | 26978485 |
| 2013-03-09 11:02:00 | Further studies are now needed to test the usefulness of DGCR6 and DGCR6L expression and alterations in the epigenome at these loci in predicting childhood anxiety and associated adult-onset pathologies in 22q11DS subjects. | 22832905 |
| 2010-06-30 22:06:00 | Observational study of gene-disease association. (HuGE Navigator) | 20398908 |
| 2010-03-22 11:30:00 | GABAB1 subunits interact with DGCR6 in the endoplasmic reticulum prior to their recruitment into functional GABAB receptors. | 20036641 |
| 2010-01-21 00:00:00 | A compelling genetic hypothesis for a complex disease: PRODH2/DGCR6 variation leads to schizophrenia susceptibility. | 11959925 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DGCR6_HUMAN,
X5D7D2_HUMAN
UniprotKB:
Q14129,
X5D7D2
UniParc:
UPI00028408BD,
UPI000000DBA4
EMBL:
BC047039,
AK315115,
AF228707,
AC007326,
CH471176,
CR456434,
KJ534820,
X96484,
KJ535003
Ensembl:
ENSG00000183628
KO:
hsa:8214
|
| Nucleutide sequences |
EMBL-CDS:
BAG37572.1,
AAH47039.1,
EAX03077.1,
EAX03075.1,
AHW56642.1,
AAK15584.1,
CAA65339.1,
CAG30320.1,
AHW56460.1
Ensembl_TRS:
ENST00000331444,
ENST00000427407
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000397633,
ENSP00000331681
RefSeq:
XP_011528696.1,
NP_005666.2
|
| Others |
UniRef100:
UniRef100_Q14129
UniRef90:
UniRef90_Q14129
UniRef50:
UniRef50_Q14129
UniGene:
Hs.474185
CCDS:
CCDS13753.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 26978485 |
Am J Med Genet B Neuropsychiatr Genet Anne Claire Richard , Anne Rovelet-Lecrux , Elsa Delaby , Camille Charbonnier , Bhooma Thiruvahindrapuram , Eli Hatchwell , Peggy S Eis , Alexandra Afenjar , Brigitte Gilbert Dussardier , Stephen W Scherer , Catalina Betancur , Dominique Campion |
2016-04-01 | - |
| 24722188 |
Nat Commun Roser Corominas , Xinping Yang , Guan Ning Lin , Shuli Kang , Yun Shen , Lila Ghamsari , Martin Broly , Maria Rodriguez , Stanley Tam , Shelly A Trigg , Changyu Fan , Song Yi , Murat Tasan , Irma Lemmens , Xingyan Kuang , Nan Zhao , Dheeraj Malhotra , Jacob J Michaelson , Vladimir Vacic , Michael A Calderwood , Frederick P Roth , Jan Tavernier , Steve Horvath , Kourosh Salehi-Ashtiani , Dmitry Korkin , Jonathan Sebat , David E Hill , Tong Hao , Marc Vidal , Lilia M Iakoucheva |
2014-01-01 |
ADA,
CDH9,
CDH10,
TRIM10,
SORBS3,
PSME3,
CALCOCO2,
SPRY2,
EFS,
IKZF1,
CDR2,
NDC80,
TACC3,
CDX4,
ZBTB18,
NEBL,
SPAG5,
RBCK1,
RAI2,
VAMP5,
CPLX1,
RCBTB2,
RBPMS,
MID2,
RAPGEF4,
KLF12,
EXOSC8,
DTX2,
GALNT13,
GPRASP2,
CMTM5,
AGAP1,
RAB3IP,
SSX2IP,
PIH1D2,
RHEBL1,
PRR20A,
FSD2,
ADORA2A,
FUNDC1,
PTCHD1,
CRMP1,
CRX,
NOL4L,
DYDC1,
MIPOL1,
MGAT5B,
CTBP1,
CTBP2,
TTC23L,
ADRB2,
AMOT,
ADSL,
SAXO1,
CCDC67,
DAB1,
DAO,
OTUD7A,
MARCH10,
AP2B1,
AES,
TXLNB,
FAM9B,
DHCR7,
DHPS,
SEPT1,
DLG2,
DLX1,
DLX2,
DMPK,
DPYD,
DPYSL2,
DRD3,
ABAT,
EDA,
EIF4E,
EIF4EBP1,
EIF4EBP2,
TXLNA,
ERBB2,
ESR2,
SPERT,
REEP3,
EEF1AKMT1,
RFX6,
FGFR3,
FHIT,
IKZF3,
IKZF2,
NTNG1,
ZBTB1,
FAN1,
RPIA,
SWAP70,
SEPT6,
CEP68,
CYFIP1,
GSE1,
FAM168A
|
| 22832905 |
Transl Psychiatry R Das Chakraborty , D Chakraborty , A J Bernal , K Schoch , T D Howard , E H Ip , S R Hooper , M S Keshavan , R L Jirtle , V Shashi |
2012-01-01 |
DGCR6,
DGCR6L
|
| 21832049 |
J Biol Chem Judit Oláh , Orsolya Vincze , Dezsõ Virók , Dóra Simon , Zsolt Bozsó , Natália Tõkési , István Horváth , Emma Hlavanda , János Kovács , Anna Magyar , Mária Szũcs , Ferenc Orosz , Botond Penke , Judit Ovádi |
2011-09-30 | - |
| 20398908 |
J Psychiatr Res Ester Saus , Anna Brunet , LluÃs Armengol , Pino Alonso , José M Crespo , Fernando Fernández-Aranda , Miriam Guitart , RocÃo MartÃn-Santos , José Manuel Menchón , Ricard Navinés , Virginia Soria , Marta Torrens , Mikel Urretavizcaya , Vicenç Vallès , Mònica Gratacòs , Xavier Estivill |
2010-10-01 |
NRG3,
GNRHR2,
GRIN3B,
NIPA1,
COMT,
CORT,
ADRA2C,
GRK3,
DLG1,
DLG2,
DRD4,
DRD5,
SDK1,
NLGN1,
FKBP5,
TFIP11,
GABBR1,
GABRG3,
GALR1,
AUTS2,
GDF2,
DISC1,
CNTN6,
GLO1,
GRIA1,
GRIA2,
GRIN2A,
GRM5,
GRM7,
GRM8,
HCRTR1,
HTR1B,
IMPA2,
ACHE,
NGF,
NOS2,
NPPC,
NPR3,
NSF,
NTSR1,
PLCB4,
PLCD1,
CNTN5,
PPP3CC,
PRODH,
S100B,
SCT,
SHMT1,
SLC1A1,
SLC1A2,
RTN4R,
SLC6A2,
SLC6A13,
SSTR5,
TACR1,
TRH,
TSNAX,
VIP,
DGCR6,
FZD9,
IMMP2L,
GALR3,
ACTN2,
NRXN3,
CRIPT,
CLINT1,
NOS1AP
|
| 20036641 |
GABA(B) receptor subunit 1 binds to proteins affected in 22q11 deletion syndrome. Biochem. Biophys. Res. Commun. Dagmar Zunner , Christina Deschermeier , Hans-Christian Kornau |
2010-03-05 |
GABBR1,
DGCR6
|
| 15821931 |
Hum. Genet. Thorsten Pfuhl , Matthias Dürr , Andreas Spurk , Björn Schwalbert , Ruth Nord , Josef Mysliwietz , Elisabeth Kremmer , Friedrich A Grässer |
2005-06-01 |
DGCR6,
DGCR6L
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 15461802 |
A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. John E Collins , Charmain L Wright , Carol A Edwards , Matthew P Davis , James A Grinham , Charlotte G Cole , Melanie E Goward , Begoña Aguado , Meera Mallya , Younes Mokrab , Elizabeth J Huckle , David M Beare , Ian Dunham |
2004-01-01 |
CHKB-AS1,
HMGXB4,
TOM1,
LOC400927-CSNK1E,
SF3A1,
CACNG2,
SLC25A17,
DDX17,
RFPL3S,
RFPL3,
RFPL2,
RFPL1S,
NUP50,
TOB2,
KDELR3,
IFT27,
CDC42EP1,
DMC1,
RABL2B,
RABL2A,
CHEK2,
CHKB,
PACSIN2,
USP18,
PHF21B,
PIK3IP1,
C1QTNF6,
C22orf39,
TANGO2,
EMID1,
ANKRD54,
COMT,
ADORA2A,
CRKL,
APOBEC3D,
ZNF280B,
CRYBA4,
CRYBB1,
CRYBB2,
CRYBB3,
CSF2RB,
CSNK1E,
CCT8L2,
LINC00896,
AIFM3,
C22orf15,
HSCB,
CCDC117,
HORMAD2,
DUSP18,
C22orf42,
ENTHD1,
DNAJB7,
FAM109B,
NFAM1,
CDPF1,
GTSE1-AS1,
CYP2D6,
ADSL,
AP1B1,
TMPRSS6,
APOBEC3H,
WBP2NL,
DDT,
POLR3H,
CYB5R3,
APOBEC3A,
APOBEC3F,
EWSR1,
MORC2,
HIC2,
GRAMD4,
TTLL12,
MLC1,
KIAA0930,
PES1,
PRAME,
SEC14L2,
RBFOX2,
SEZ6L,
RASD2,
PATZ1,
SH3BP1,
TSSK2,
SDF2L1,
PPIL2,
PITPNB,
PISD,
IL17RA,
BRD1,
BCL2L13,
TFIP11,
PRR14L,
SERHL2,
XRCC6,
TMEM211,
C22orf31,
TBC1D22A,
CBY1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员