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81285 OR51E2

81285

OR51E2

olfactory receptor family 51 subfamily E member 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition olfactory receptor family 51 subfamily E member 2

研究结论

Date Results Publications
2021-01-16 16:00:00 Exosome carrying PSGR promotes stemness and epithelial-mesenchymal transition of low aggressive prostate cancer cells. 33164833
2020-07-13 07:32:00 Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer. We identified 24 agonists and 1 antagonist for this receptor. We detected that agonist 19-hydroxyandrostenedione, a product of the aromatase reaction, is endogenously produced upon receptor activation and contributes to neuroendocrine transdifferentiation of prostate cancer LNCaP cells. 29892571
2018-06-02 10:26:00 Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells. In a heterologous expression system, OR51E2 trafficked readily to the cell surface and showed ligand selectivity and sensitivity to the short chain fatty acids (SCFAs) acetate and propionate. 27905542
2018-05-19 10:05:00 OR51E2 is involved in the regulation of cell proliferation and migration in human primary melanoma and melanoma metastasis 28191688
2017-10-14 13:10:00 Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with prostate cancer. 28910345

名称对应

Type IDs
Synonymous HPRAJ, OR51E3P, OR52A2, PSGR
Gene
UniProtKB-ID: O51E2_HUMAN, A0A126GVK0_HUMAN
UniprotKB: Q9H255, A0A126GVK0
UniParc: UPI000003B49B
EMBL: AY033942, CH471064, BK004368, BC020768, AF369708, KP290277, AK314051, AF311306
Ensembl: ENSG00000167332
KO: hsa:81285
Nucleutide sequences
EMBL-CDS: AAH20768.1, EAW68829.1, AAK38728.1, BAG36760.1, AAK57550.1, AAG40776.1, DAA04766.1, ALI87456.1
Ensembl_TRS: ENST00000396950, ENST00000641638
Protein sequencees
Ensembl_PRO: ENSP00000493442, ENSP00000380153
RefSeq: NP_110401.1
Others
UniRef100: UniRef100_Q9H255
UniRef90: UniRef90_Q9H255
UniRef50: UniRef50_Q9H255
UniGene: Hs.501758, Hs.606330
CCDS: CCDS7751.1

全选

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研究热度

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