Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis.

Exp. Dermatol.2017 Jul;26(7):569-576. doi:10.1111/exd.13316. Epub 2017 Apr 21

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signal depends on the activation of OR51E2. Furthermore, OR51E2 activation inhibits the growth of VGP melanoma cells via apoptotic processes. Cell motility assays revealed that treatment with Î²-ionone decreases the migration of VGP melanoma cells. Overall, our data demonstrates that OR51E2 is involved in the regulation of cell proliferation and migration, suggesting that it may serve as a novel target for melanoma therapy.

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Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis.

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